Basic & Clinical Medicine ›› 2011, Vol. 31 ›› Issue (10): 1161-1164.

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Parkinson’s disease and advances in ATP13A2 gene research

  

  • Received:2010-04-29 Revised:2010-09-13 Online:2011-10-05 Published:2011-10-08

Abstract: Parkinson’s disease (PD) is the second most frequent neurodegenerative disease after Alzheimer’s disease, with the cause is the co-activation of environmental and genetic factors. Sixteen gene loci and 11 disease genes have been identified. ATP13A2 gene located on PARK9 implicated in Kufor-Rakeb syndrome (KRS)and early-onset Parkinson’s disease(EOPD). This review will describe the advances concerning the ATP13A2 mutations in PD patients and function of this gene.

Key words: Parkinson’s disease, Kufor-Rakeb syndrome, EOPD, the ATP13A2 gene, metal cations

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