Abstract: Abstract: Objective Explore Stathmin in non-small cell lung cancer (NSCLC) organization and normal tissue the expression, understand its with NSCLC clinical and pathological features of the relationship between them. Method Using immunohistochemistry and RT - PCR method, detection 43 patients with NSCLC postoperative cancerous tissue and normal tissue samples in Stathmin protein and mRNA expression. Results Stathmin protein and gene in NSCLC positive expression rate respectively 67.44%, 62.79% and significantly higher than normal tissues 16.28% and 20.93% (P < 0.01), its expression and tumor cell differentiation degree and without lymph node metastasis relevant (P < 0.05). Conclusion Stathm in in NSCLC happening development process has played an important role, he may become prediction NSCLC aggressieness of new biology and tailored therapies sensitive indicators.

Key words: Key words: tathmin, NSCLC, Immunohistochemistry, RT-PCR