Research progress on the role of Klotho in heart failure

doi:10.16352/j.issn.1001-6325.2023.06.0998

Abstract

Abstract: Klotho is an anti-aging protein and can be divided into three types: full-length transmembrane Klotho, soluble Klotho and secreted Klotho. Many studies have shown that Klotho is closely related to oxidative stress, inflammatory response, myocardial hypertrophy, fibrosis, autophagy, and mitochondrial dysfunction. It is also involved in the occurrence and development of heart failure. It is expected to provide a new target and direction for the treatment of heart failure.

Key words: Klotho, anti-aging protein, heart failure

CLC Number:

R542

CHAI Yaru, DENG Yuting, DAI Hongyan, GUAN Jun. Research progress on the role of Klotho in heart failure[J]. Basic & Clinical Medicine, 2023, 43(6): 998-1002.

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URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/10.16352/j.issn.1001-6325.2023.06.0998

http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2023/V43/I6/998

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