Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (3): 486-489.doi: 10.16352/j.issn.1001-6325.2023.03.486

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Recent progress of the role of ferroptosis in the pathogenesis of early brain injury after subarachnoid hemorrhage

QU Dapeng1, SUN Huiyan2, LI Qiang3*, WANG Hongquan4   

  1. 1. Department of Emergency Medicine;
    3. Department of Neurology, the Affiliated Hospital of Chifeng University, Chifeng 024005;
    2. Health Science Center, Chifeng University, Chifeng 024000;
    4. Department of Neurology, Aerospace Center Hospital, Aerospace School of Clinical Medicine, Peking University, Beijing 100049,China
  • Received:2022-06-28 Revised:2022-11-30 Online:2023-03-05 Published:2023-02-27
  • Contact: *

Abstract: Subarachnoid hemorrhage (SAH) leads to ferroptosis with clinical evidence like iron metabolism deregulation, increased lipid peroxitation(LPO) and the inhibition of glutathione/glutathione peroxides 4(GSH/GPX4). Ferroptosis mediated early brain injury (EBI) may occur in the 72-hour period following SAH (EBI-SAH) leads to the poor prognosis of SAH. Pharmacological targeting at ferroptosis mitigate EBI-SAH, provides a new target for future treatment and prevention of EBI-SAH through targeting at ferroptosis.

Key words: subarachnoid hemorrhage, early brain injury, ferroptosis, ferroptosis inhibitor

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