Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (3): 476-480.doi: 10.16352/j.issn.1001-6325.2023.03.476

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Research progress on the role of endoplasmic reticulum stress in osteoarthritis

JIN Tao1,2, YANG Qingshan2, WU Shujin3, ZHU Xiaoyan1, SHI Yucong1, NIU Jianxiong1, LIU Lin2*   

  1. 1. The First Clinical College, Gansu University of Traditional Chinese Medicine, Lanzhou 730000;
    2. Department of Orthopedics, Gansu Provincial People's Hospital, Lanzhou 730000;
    3. School of Pharmacy, Lanzhou University, Lanzhou 730000, China
  • Received:2021-12-13 Revised:2022-05-07 Online:2023-03-05 Published:2023-02-27
  • Contact: *

Abstract: Osteoarthritis is a common degenerative disease in which endoplasmic reticulum stress(ER stress) plays an important role in the pathogenesis of chondrocyte apoptosis. To limit the adverse effects of endoplasmic reticulum stress, cells activate the unfolded protein response (UPR). However, when endoplasmic reticulum stress persists beyond the maximum tolerance of UPR, cells may trigger endoplasmic reticulum dysfunction through three pathways of UPR leading to chondrocyte apoptosis.

Key words: osteoarthritis, chondrocyte apoptosis, endoplasmic reticulum stress, unfolded protein response

CLC Number: