Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (1): 192-195.doi: 10.16352/j.issn.1001-6325.2023.01.0192

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Research advances in the treatment of lung diseases based on mesenchymal stem cell exosomes

CHEN Lili1,SUN Yonghong2*,LEI Xiaoyan2,WANG Jianjun2,CHEN Xingxing2,BAO Baixin1   

  1. 1. First College of Clinical Medicine,Gansu University Traditional Chinese Medicine,Lanzhou 730000;
    2. Department of Pediatrics, Gansu Provincial Peoples Hospital,Lanzhou 730000,China
  • Received:2022-04-02 Revised:2022-09-29 Published:2022-12-27
  • Contact: *

Abstract: Exosomes secreted by mesenchymal stem cell(MSC-EXOs)carry lipids,proteins,nucleic acids and other signaling substances, which play an important role in intercellular communication, immune regulation and vascular regeneration. MSC-EXOs in pulmonary hypertension, pulmonary fibrosis and other lung diseases can improve the function of the lung tissue and treat lung diseases by regulating different signaling pathways, reducing cell inflammatory reaction, regulating immune function, improving the function of mitochondria, promoting angiogenesis, reducing pulmonary vascular remodeling and etc.,which provides new ideas for the treatment of refractory lung diseases in the future.

Key words: mesenchymal stem cell, exosome, lung disease

CLC Number: