Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (12): 1950-1954.doi: 10.16352/j.issn.1001-6325.2022.12.1950

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Research progress of oxidative stress increasing the risk of cardiovascular disease of polycystic ovary syndrome patients

LI Huan-huan1,2, ZHANG Yu-qi1,2, LYU Hai-hong2*   

  1. 1. the First Clinical Medical School, Lanzhou University, Lanzhou 730000;
    2. Department of Endocrinology,the First Hospital of Lanzhou University,Lanzhou 730000,China
  • Received:2021-07-28 Revised:2021-12-08 Online:2022-12-05 Published:2022-11-23
  • Contact: *

Abstract: Polycystic ovary syndrome (PCOS) is related to obesity, hyperinsulinemia, impaired glucose toler-ance, hyperandrogenism, chronic inflammatory response, dyslipidemia and hypertension. PCOS is critically associated with oxidative stress (OS), which is a risk factor for cardiovascular disease (CVD). This article reviews the mechanisms by which OS increases the risk of CVD in PCOS and the possibility of preventing CVD in PCOS patients by blocking the pathway of reactive oxygen species (ROS) production.

Key words: polycystic ovary syndrome, oxidative stress, endothelial dysfunction, atherosclerosis

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