Abstract: Objective To investigate whether puerarin (PUE) can alleviate lipopolysarccharide(LPS)-induced renal inflammatory response in mice. Methods Thirty health control, 45 severe infection with no renal injury(N-SI group), 30 severe infection with renal injury(SI group) were enrolled in this study, Serum samples were collected. 50 mice were randomly divided into 5 groups, including control(Ctrl) group, LPS group, and LPS+PUE(10, 25, 50 mg/kg·d, IP) groups. PUE was applied 1 h after LPS administration. And mice were sacrificed after 24 h and blood sample was collected. MDA, SOD, IL-33 and IL-6 expression were detected by ELISA. Results BUN, Scr, IL-6 and IL-33 in SI group were significantly increased compared with control group and N-SI group (P＜0.05). BUN and Scr of LPS group were significantly increased compared with control group. PUE decreased BUN, Scr, MDA, IL-33 and IL-6 expression and increased activity of SOD as compared with LPS group(P＜0.05). Conclusions PUE can alleviate LPS-induced renal inflammatory response in mice.

Key words: puerarin, lipopolysarccharide(LPS), inflammation response