Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (10): 1596-1600.doi: 10.16352/j.issn.1001-6325.2022.10.1596

• Mini Reviews • Previous Articles     Next Articles

Research advances on Rab protein involved in intracellular phagocytosis of Mycobacterium tuberculosis

SUN Qiao-ling, YUAN Xin, QIN Huan, WANG Yu*   

  1. Department of Microbiology, College of Basic Medicine, Zunyi Medical University, Zunyi 563003, China
  • Received:2021-07-16 Revised:2021-11-12 Online:2022-10-05 Published:2022-09-23
  • Contact: *

Abstract: Mycobacterium tuberculosis(M.tuberculosis, Mtb)is the causative agent of tuberculosis and can survive through regulating intracellular phagocytosis and affect the biological function of host cells. Rab proteins are important components of intracellular membrane transport and involved in the phagocytosis of Mtb. This review summarized the effect of Mtb and its compositions on intracellular phagocytosis and the role of Rab in this process. Thus this review may provide some ideas to understand the relationship between Rab proteins and the phagocytosis of Mtb, and to provide new thoughts and potential targets based on exploring the intracellular immune mechanism of Mtb.

Key words: Mycobacterium tuberculosis, bacterium components, Rab protein, phagocytosis

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