Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (10): 1591-1595.doi: 10.16352/j.issn.1001-6325.2022.10.1591

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Progress in research on m6A modification of FTO mediated-RNA and development

PAN Ming-min, WANG Qi-yang, YANG Li-ping*   

  1. Department of Integrated Chinese and Western Medicine, Henan University of Chinese Medicine, Zhengzhou 450046,China
  • Received:2021-04-25 Revised:2021-10-15 Online:2022-10-05 Published:2022-09-23
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Abstract: Human fat mass and obesity associated protein FTO is the first confirmed N6-methyladenosine(m6A) demethylase, which demonstrated the existence of reversible RNA modification, and also unveiled the prelude of m6A modification research. More and more researchers have tried to explore the specific mechanism of gene expression regulation at the level of m6A modification. It is found that m6A modification function requires the joint participation of methylesterase, demethylase, and binding protein to complete. FTO catalyze the demethylation of m6A modifications on mRNAs and is widely expressed in human tissues and participate in the regulation of various biological processes. This paper outlines the relationship between demethylase FTO and its mediated m6A/RNA modification and the development of body fat tissue, embryonic tissue, brain and neuro-system, hoping to gain insight into the function and mechanism of FTO.

Key words: FTO, mRNA, m6A, development

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