Function of the microglia in neuroinflammation of Alzheimer's disease:a brief review

doi:10.16352/j.issn.1001-6325.2022.08.1310

Abstract

Abstract: Different types of activated imbroglio exist in the brain of the patients with Alzheimer's disease (AD). As the neuroinflammation reaction progresses, significant changes take place in the morphology and function of those cells. They could play a pathogenic role by altering the phagocytic function of cells, including intracellular toxic reactions or directly participate in immune response. Several clinical trials have been conducted to promote targeted therapy focusing on the role that microglia played in neuroinflammation reactions of AD. More large scale studies are necessary to elucidate the function and mechanism of microglia in the neuroinflammation reaction of AD.

Key words: Alzheimer's disease, microglia, neuroinflammation

CLC Number:

R741.02

WANG Yuan-zhuo, ZHENG Qing-yue, ZHANG Han-lin, QIU Wen-ying, WANG Tao, MA Chao. Function of the microglia in neuroinflammation of Alzheimer's disease:a brief review[J]. Basic & Clinical Medicine, 2022, 42(8): 1310-1313.

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URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/10.16352/j.issn.1001-6325.2022.08.1310

http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2022/V42/I8/1310

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