Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (8): 1306-1309.doi: 10.16352/j.issn.1001-6325.2022.08.1306

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Advances of research on the function of RNA binding proteins in the pathogenesis of thyroid carcinoma

ZHOU Mei-cen*, LAN Ling, DENG Wei   

  1. 1. Department of Endocrinology, Beijing Jishuitan Hospital, the Fourth Clinical College of Peking University, Beijing 100035, China
  • Received:2021-01-04 Revised:2021-07-19 Online:2022-08-05 Published:2022-08-01
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Abstract: RNA-binding protein (RBP) plays an important role in the pathogenesis of thyroid cancer. It can regulate the intracellular activities such as transcription, nuclear output, alternative splicing and translation of mRNA from tumor-related genes at the post-transcriptional or translation levels, and then regulate the proliferation, apoptosis and migration of thyroid cancer, thereby promoting or inhibiting the occurrence of tumors. Clinically, a series of RBP molecules are significantly correlated with the classification and prognosis of patients with thyroid cancer and may support the oncological classification, evaluation and prediction of prognosis of thyroid cancer.

Key words: RNA-binding protein, thyroid carcinoma, tumor growth

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