Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (7): 1042-1046.doi: 10.16352/j.issn.1001-6325.2022.07.1042

• Original Articles • Previous Articles     Next Articles

Timed Up and Go test is associated with cognitive impairment in elders from East China

LIU Yan-li1, MA Ya-jun2, PAN Yan2, ZHAO Rui-xue2, ZHAO Tun2, JIANG Xiao-yan3, LI Shu-juan4*   

  1. 1. Department of Neurology, Beijing Huairou District Hospital, Beijing 101400;
    2. Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020;
    3. Key Laboratory of Arrhythmias, Ministry of Education, Department of Pathology and Pathophysiology, School of Medicine, Tongji University, Shanghai 200092;
    4. Department of Neurology, Fuwai Hospital, National Center for Cardiovascular Diseases, CAMS & PUMC, Beijing 100034, China
  • Received:2022-04-07 Revised:2022-05-19 Online:2022-07-05 Published:2022-06-29
  • Contact: *

Abstract: Objective To explore a potential relationship of Timed Up and Go (TUG) test to cognitive functions among elders. Methods The participants were from Rugao Longevity and Ageing Study conducted in Jiangsu province, China. TUG test was completed, recording gaits stability, test time and the overall scale. Cognitive function was evaluated using Chinese version of revised Hasegawa's Dementia Scale (HDS-R). Results A total of 1 655 participants (aged 75-84 years old) completed the TUG test and cognitive evaluation were included in this study. Among them, 872(52.7%) in cognitive impairment group and 783(47.3%) in non-cognitive impairment group, the gait stability, time and scale of TUG test were inverse associated with HDS-R and its subcomponents, respectively(P<0.001). Logistic regression analysis showed that unsteady gait(OR=1.11, 95% CI:1.08-1.14, P<0.001), longer time (OR=2.50, 95% CI:1.76-3.55, P<0.001) and deteriorated scale (OR=1.62, 95% CI:1.39-1.89, P<0.001) in TUG test were independently associated with increased risk of cognitive impairment. Conclusions Worse motor function performance on TUG test is significantly associated with cognitive impairment. The application of TUG test is potential method in early risk screening of cognitive impairment in community and has certain feasibility.

Key words: cognitive impairment, motor function, Timed Up and Go (TUG) test, aging, decline

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