Abstract: Objective The multiadhesion extracellular matrix protein LAMC2 was systematically analyzed with multiple databases. Multiple omics data demonstrates that LAMC2 is a key molecule affecting tumor development and clinical prognosis of patients. Methods The protein and RNA expressions of LAMC2 in various tumors and normal tissues were analyzed by database. The relationship between LAMC2 expression and survival rate of patients with different tumor types was investigated and immune infiltration analysis was performed. Finally, relationship between LAMC2 expression and immune invasion in tumor microenvironment of different tumor types was investigated. Results The expression of LAMC2 mRNA and protein was found to be higher in many tumors than in adjacent tissues and concentrated in malignant tumor cells in some tumors. In addition, LAMC2 expression has been found to be detrimental to the clinical prognosis of generalized carcinoma and was associated with immune invasion of various tumors. Conclusions LAMC2 is an important oncogene and may be an important target for effective treatment of tumors. These results provide a theoretical basis for subsequent molecular targeted therapy.

Key words: LAMC2, diffuse carcinoma analysis, prognostic analysis