Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (3): 507-511.doi: 10.16352/j.issn.1001-6325.2022.03.007

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Advances on the roles of circular RNA in breast cancer

HE Xiao, HU Wei-jie, LYU Wen-chang, REN Yu-ping, WU Min, WU Yi-ping, ZHANG Qi*   

  1. Department of Plastic Surgery, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China
  • Received:2020-09-15 Revised:2021-04-06 Online:2022-03-05 Published:2022-03-04
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Abstract: Circular RNA (circRNA) is a kind of non-coding RNA with circular structure and is found in a variety of cell types. CircRNA is characterized by diversity, specificity, conservatism and stability. As an emerging non-coding regulatory molecules, circRNA can regulate the proliferation and metastasis of breast cancer (BC) mainly through the mechanism of competitive endogenous RNA, and is involved in a variety of chemotherapy resistance and affect the efficacy. Elucidating the functions and mechanisms of circRNA in BC may provide novel and effective strategies for the diagnosis and treatment of BC.

Key words: breast cancer, circular RNA, competitive endogenous RNA, chemotherapy resistance

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