C-erbB-2表达在胃癌预后作用中的meta分析

基础医学与临床 ›› 2007, Vol. 27 ›› Issue (9): 1029-1032.

C-erbB-2表达在胃癌预后作用中的meta分析

秦桂萍路喜安齐广强曲成毅梁建芳李士瑛

山西医科大学山西医科大学第一附属医院病理科山西医科大学第一附属医院病理科山西医科大学流行病学教研室山西医科大学第一附属医院病理科山西医科大学，病理学教研室

收稿日期:2006-01-23 修回日期:2007-01-22 出版日期:2007-09-25 发布日期:2007-09-25
通讯作者: 秦桂萍

Significance of c-erbB-2 protein expression on the prognosis of gastric carcinoma: a Meta-analysis study

Gui-ping Qin Xi-an Lu Guang-qiang Qi Cheng-yi Qu Jian-fang Liang Shi-ying Li

Department of Pathology,Renmin hospital of linfen Department of Pathology,Renmin hospital of linfen Department of Pathology,The First Hospital

Received:2006-01-23 Revised:2007-01-22 Online:2007-09-25 Published:2007-09-25
Contact: Gui-ping Qin

摘要/Abstract

摘要： 目的评价c-erbB-2蛋白表达与胃癌预后的关联性。方法利用RevMan4．2软件对近15年国内外发表的有关c-erbB-2与胃癌预后研究的入选11篇文章进行综合分析。结果 11篇文献5年生存率合并OR值为0．69（95%CI：0．54－0．87）；其中3篇以5年生存率为终末指标、以OR值为关联指标的文献，其5年生存率合并OR值为0．67（95％CI：0．48－0．94）；高分化胃癌组和进展期胃癌组5年生存率合并OR值为0．18（95％CI：0．09－0．38）和0．72（95％CI：0．47－1．09）。结论 C-erbB-2表达可能与胃癌预后呈负相关。

Abstract: Objective To evaluate the association of c-erbB-2 protein expression with the prognosis of gastric carcinoma. Methods 11 Literatures was analyzed quantitively which published last 15 years on the relationship of c-erbB-2 with prognosis by software RevMan. Results The pooled odds ratio(OR) of 5-year survival rates was 0.69（95%CI：0.54－0．87）for all 11 literatures. The pooled odds ratio(OR) of three literatures from eleven literatures was 0．67（95％CI：0．48－0．94）which 5-year survival rates was determined as final index and OR as associated．For well-differentiated and advanced gastric carcinoma, the pooled odds ratio(OR) of 5－year survival rates were 0．18（95％CI：0．09－0．38）and 0.72(95％CI：0.47－1.09)respectively．Conclusion The association of c-erbB-2 expression with prognosis of gastric carcinoma may be negative．

秦桂萍路喜安齐广强曲成毅梁建芳李士瑛. C-erbB-2表达在胃癌预后作用中的meta分析[J]. 基础医学与临床, 2007, 27(9): 1029-1032.

Gui-ping Qin Xi-an Lu Guang-qiang Qi Cheng-yi Qu Jian-fang Liang Shi-ying Li. Significance of c-erbB-2 protein expression on the prognosis of gastric carcinoma: a Meta-analysis study[J]. Basic & Clinical Medicine, 2007, 27(9): 1029-1032.