基础医学与临床 ›› 2009, Vol. 29 ›› Issue (1): 106-108.

• 短篇综述 • 上一篇    

黏着斑激酶与纤维化

敦志娜 张晓岚   

  1. 河北医科大学第二医院消化内科 河北医科大学第二医院消化内科
  • 收稿日期:2008-01-14 修回日期:2008-03-24 出版日期:2009-01-25 发布日期:2009-01-25
  • 通讯作者: 张晓岚

Focal Adhesion Kinase and Fibrosis

Zhi-na DUN, Xiao-lan ZHANG   

  1. Dept. Gastroenterology, the Second Hospital, Hebei medical University Dept. Gastroenterology, the Second Hospital, Hebei medical University
  • Received:2008-01-14 Revised:2008-03-24 Online:2009-01-25 Published:2009-01-25
  • Contact: Xiao-lan ZHANG

摘要: 黏着斑激酶(FAK)是一种非受体胞质酪氨酸蛋白激酶,处于细胞内多条信号传导通路的交汇点,活化后可调节多种细胞生物学行为。研究发现,FAK在多种纤维化疾病的发生发展中发挥重要作用,有可能成为纤维化疾病治疗的新途径。

关键词: 粘着斑激酶, 纤维化

Abstract: Focal adhesion kinase (FAK), a non-receptor protein tyrosine kinase, is at the cross of the numerous intra-cellular signal transduction. The activated FAK has been implicated in a diverse array of cellular behavious. Advanced relevant observations of FAK and fibrosis show that FAK plays an important role in fibrosis disease, the targeting of FAK may represents a novel therapeutic strategy.

Key words: focal adhesion kinase, fibrosis