基础医学与临床 ›› 2009, Vol. 29 ›› Issue (1): 106-108.
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敦志娜 张晓岚
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Zhi-na DUN, Xiao-lan ZHANG
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摘要: 黏着斑激酶(FAK)是一种非受体胞质酪氨酸蛋白激酶,处于细胞内多条信号传导通路的交汇点,活化后可调节多种细胞生物学行为。研究发现,FAK在多种纤维化疾病的发生发展中发挥重要作用,有可能成为纤维化疾病治疗的新途径。
关键词: 粘着斑激酶, 纤维化
Abstract: Focal adhesion kinase (FAK), a non-receptor protein tyrosine kinase, is at the cross of the numerous intra-cellular signal transduction. The activated FAK has been implicated in a diverse array of cellular behavious. Advanced relevant observations of FAK and fibrosis show that FAK plays an important role in fibrosis disease, the targeting of FAK may represents a novel therapeutic strategy.
Key words: focal adhesion kinase, fibrosis
敦志娜 张晓岚 . 黏着斑激酶与纤维化[J]. 基础医学与临床, 2009, 29(1): 106-108.
Zhi-na DUN; Xiao-lan ZHANG. Focal Adhesion Kinase and Fibrosis[J]. Basic & Clinical Medicine, 2009, 29(1): 106-108.
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