基础医学与临床 ›› 2007, Vol. 27 ›› Issue (12): 1373-1376.

• 研究论文 • 上一篇    下一篇

左氧氟沙星延长离体豚鼠乳头肌的动作电位时程

尚曙玉 韩圣娜 景莹 韦迎娜 成树模 乔鹏 张朝   

  1. 郑州大学医学院生理教研室 郑州大学医学院生理教研室 郑州大学医学院生理教研室 郑州大学医学院生理教研室 郑州大学医学院生理教研室 郑州大学医学院生理教研室 南京师范大学生命科学院江苏省分子医学生物技术重点实验室
  • 收稿日期:2006-09-26 修回日期:2007-01-16 出版日期:2007-12-25 发布日期:2007-12-25
  • 通讯作者: 张朝

Levofloxacin Prolonged Cardiac Action Potential Duration in Guinea Pig Papillary Muscles

Shu-yu SHANG, Sheng-na HAN, Ying JING, Ying-na WEI, Shu-mo CHENG, Peng QIAO, Zhao ZHANG   

  1. Department of physiology, Basic Medical College, Zhengzhou University, Zhengzhou 450052
  • Received:2006-09-26 Revised:2007-01-16 Online:2007-12-25 Published:2007-12-25
  • Contact: Zhao ZHANG

摘要: 目的 观察左氧氟沙星(LVFX)对豚鼠心肌动作电位的影响,并以司帕沙星(SPX)为阳性对照物比较二者对心肌的毒性作用。方法 微电极记录豚鼠右心室乳头动作电位。结果 刺激频率为1Hz时,各浓度的SPX均显著性延长APD50和APD90,而LVFX浓度超过10μmol/L时明显延长APD50和APD90。 随着刺激频率的减慢,LVFX和SPX均呈逆频率依赖性延长APD90。结论 LVFX和SPX均引起APD延长,前者效应较后者为弱,仅在大剂量时有导致QT间期延长的潜在毒性。

Abstract: Objective To compare cardiaotoxic effect with sparfloxacin, the effects of levofloxacin on cardiac action potentials were examined. Methods Action potentials were recorded from isolated papillary muscles of guinea pig right ventricles by using conventional microelectrode techniques. Results With a stimulation frequency of 1Hz, both APD50 and APD90 were prolonged at any used concentrations, While, at the concentrations over 10μmol/L, levofloxacin prolonged the APD50 and APD90. With the stimulation frequency decreased, the prolongation of APD90 caused by LVFX or SPX were increased,indicating an inverse frequency dependency. Conclusion: LVFX has less potency to prolong APD as compare to SPX .