SARS男性患者睾丸组织的病理改变

基础医学与临床 ›› 2007, Vol. 27 ›› Issue (1): 40-43.

SARS男性患者睾丸组织的病理改变

祁丽花迟晓春徐健

北京大学医学部组胚教研室北京北京大学医学部组胚教研室北京北京大学基础医学院组织学与胚胎学教研室北京

收稿日期:2005-06-16 修回日期:2006-06-20 出版日期:2007-01-25 发布日期:2007-01-25
通讯作者: 祁丽花

Pathological changes of testis tissue in male SARS patients

Received:2005-06-16 Revised:2006-06-20 Online:2007-01-25 Published:2007-01-25

摘要/Abstract

摘要： 目的研究严重急性呼吸综合征（SARS）男性患者睾丸组织的病理变化。方法对5例SARS死亡患者的睾丸组织进行常规组织学、TUNEL及免疫组化染色。结果 5例SARS患者睾丸生精小管基膜增厚、纤维化，生精上皮坏死、脱落，睾丸中几乎未见精子。生精细胞凋亡大量增加（P<0.05），间质充血，睾丸组织中有明显的白细胞浸润。CD3+T淋巴细胞、CD68+巨噬细胞较对照组明显增多（P<0.05）, 并浸润到生精小管中。结论 SARS导致男性患者并发睾丸炎。

Abstract: Ojective To study the pathological changes of testis tissue in male SARS patients. Methods Tissue specimens were studied by HE staining、TUNEL and immunohistochemistry(IHC). Results All testes from the SARS patients demonstrated that widespead germ cells destruction,few or no spermatozoon in the seminiferous epithelium and the lumen, thickened basement membrane、 peritubular fibrosis、 vascular congestion and leukocytes infiltration obviously. The apoptotic seminiferous cells increased significantly(P<0.05).The numbers of CD3+ T lymphocyte and CD68+ macrophage increased significantly in the interstitial tissue compared with the control group(P<0.05), and both cells were observed infiltration in the tubules. Conclusions Our study implied that SARS caused orchitis.

祁丽花迟晓春徐健. SARS男性患者睾丸组织的病理改变[J]. 基础医学与临床, 2007, 27(1): 40-43.

. Pathological changes of testis tissue in male SARS patients[J]. Basic & Clinical Medicine, 2007, 27(1): 40-43.