肌源性因子调控骨代谢的研究进展

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (12): 1809-1812.

肌源性因子调控骨代谢的研究进展

周冰娜, 李梅^*

中国医学科学院北京协和医学院北京协和医院内分泌科国家卫生健康委员会内分泌重点实验室,北京 100730

收稿日期:2020-09-07 修回日期:2020-12-15 发布日期:2021-12-03
通讯作者: *limeilzh@sina.com
基金资助:
国家重点研发计划(2018YFA0800801);国家自然科学基金(81873668,82070908);北京市自然科学基金(7202153)

Research advance of myokines on bone metabolism regulation

ZHOU Bing-na, LI Mei^*

Department of Endocrinology,Key Laboratory of Endocrinology of National Health Commission,Peking Union Medical College Hospital,CAMS ＆ PUMC,Beijing 100730,Chin

Received:2020-09-07 Revised:2020-12-15 Published:2021-12-03
Contact: *limeilzh@sina.com

摘要/Abstract

摘要： 骨骼和肌肉息息相关,肌肉可合成和分泌多种肌源性因子,对骨骼的生长、发育、功能产生重要影响。肌源性因子种类繁多,可调节成骨细胞、破骨细胞和骨细胞的功能,分为促进骨骼合成代谢、骨骼分解代谢或对骨转换具有双重调控作用的因子。本文综述对骨代谢具有重要调控作用的肌源性因子的最新研究进展,以揭示肌肉与骨骼间的调控网络,为治疗肌肉骨骼疾病提供新的靶点。

关键词: 肌源性因子, 肌肉, 骨骼, 骨代谢

Abstract: Bone and muscle are closely interrelated.Muscle can synthesize and secrete a series of myokines,which play important roles on the growth,development and function of the bone.Myokines can regulate the function of osteoblasts,osteoclasts and osteocytes,which can be divided into factors that promote bone anabolism,increase bone catabolism or regulate bone turnover in a double-edged way.This article reviews the advance of myokines which have important regulatory effects on bone metabolism,to reveal the regulatory network between muscle and bone,and provide new targets for the treatment of musculoskeletal diseases.

Key words: myokines, muscle, bone, bone metabolism

中图分类号:

R337

周冰娜, 李梅. 肌源性因子调控骨代谢的研究进展[J]. 基础医学与临床, 2021, 41(12): 1809-1812.

ZHOU Bing-na, LI Mei. Research advance of myokines on bone metabolism regulation[J]. Basic & Clinical Medicine, 2021, 41(12): 1809-1812.

参考文献

[1]中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊疗指南(2017)[J].中华骨质疏松和骨矿盐疾病杂志,2017,10:413-444.
[2]中华医学会骨质疏松和骨矿盐疾病分会.肌少症共识[J].中华骨质疏松和骨矿盐疾病杂志,2016,9:215-227.
[3]Lima RM,Oliveira RJ,Raposo R,et al.Stages of sarcopenia,bone mineral density,and the prevalence of osteoporosis in older women[J].Arch Osteoporos,2019,14:38.doi: 10.1007/s11657-019-0591-4.
[4]Herrmann M,Engelke K,Ebert R,et al.Interactions between muscle and bone-where physics meets biology[J]. Biomolecules,2020,10:432.doi: 10.3390/biom10030432.
[5]Pedersen BK,Akerström TC,Nielsen AR,et al.Role of myokines in exercise and metabolism[J]. J Appl Physiol (1985),2007,103:1093-1098.
[6]Gomarasca M,Banfi G,Lombardi G.Myokines:the endocrine coupling of skeletal muscle and bone[J]. Adv Clin Chem,2020,94:155-218.
[7]Colaianni G,Mongelli T,Cuscito C,et al.Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice[J]. Sci Rep,2017,7:2811.doi: 10.1038/s41598-017-02557-8.
[8]Zhu J,Wang Y,Cao Z,et al.Irisin promotes cementoblast differentiation via p38 MAPK pathway[J]. Oral Dis,2020,26:974-982.
[9]Kim H,Wrann CD,Jedrychowski M,et al.Irisin mediates effects on bone and fat via αV integrin receptors[J].Cell,2018,175:1756-1768.
[10]Ma Y,Qiao X,Zeng R,et al.Irisin promotes proliferation but inhibits differentiation in osteoclast precursor cells[J]. FASEB J,2018,32:5813-5823.
[11]Hamrick MW,McGee-Lawrence ME.Blocking bone loss with l-BAIBA[J]. Trends Endocrinol Metab,2018,29:284-286.
[12]Kitase Y,Vallejo JA,Gutheil W,et al.β-aminoisobutyric Acid,l-BAIBA,is a muscle-derived osteocyte survival factor[J]. Cell Rep,2018,22:1531-1544.
[13]Han XG,Wang DK,Gao F,et al.Bone morphogenetic protein 2 and decorin expression in old fracture fragments and surrounding tissues[J]. Genet Mol Res,2015,14:11063-11072.
[14]Ruehle MA,Li MA,Cheng A,et al.Decorin-supplemented collagen hydrogels for the co-delivery of bone morphoge-netic protein-2 and microvascular fragments to a composite bone-muscle injury model with impaired vascularization[J]. Acta Biomater,2019,93:210-221.
[15]Fife E,Kostka J,Kroc Ł,et al.Relationship of muscle function to circulating myostatin, follistatin and GDF11 in older women and men[J]. BMC Geriatr,2018,18:200.doi: 10.1186/s12877-018-0888-y.
[16]Chen YS,Guo Q,Guo LJ,et al.GDF8 inhibits bone formation and promotes bone resorption in mice[J]. Clin Exp Pharmacol Physiol,2017,44:500-508.
[17]Qin Y,Peng Y,Zhao W,et al.Myostatin inhibits osteoblastic differentiation by suppressing osteocyte-derived exosomal microRNA-218:a novel mechanism in muscle-bone communication[J]. J Biol Chem,2017,292:11021-11033.
[18]Dankbar B,Fennen M,Brunert D,et al.Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice[J]. Nat Med,2015,21:1085-1090.
[19]Jung TW,Lee SH,Kim HC,et al.METRNL attenuates lipid-induced inflammation and insulin resistance via AMPK or PPARδ-dependent pathways in skeletal muscle of mice[J]. Exp Mol Med,2018,50:122.doi: 10.1038/s12276-018-0147-5.
[20]Gong W,Liu Y,Wu Z,et al.Meteorin-like shows unique expression pattern in bone and its over-expression inhibits osteoblast differentiation[J]. PLoS One,2016,11:e0164446.doi: 10.1371/journal.pone.0164446.
[21]Okabe I,Kikuchi T,Mogi M,et al.IL-15 and RANKL Play a synergistically important role in osteoclastogenesis[J]. J Cell Biochem,2017,118:739-747.
[22]Feng S,Madsen SH,Viller NN,et al.Interleukin-15-activated natural killer cells kill autologous osteoclasts via LFA-1, DNAM-1 and TRAIL, and inhibit osteoclast-mediated bone erosion in vitro[J]. Immunology,2015,145:367-379.
[23]Kirk B,Feehan J,Lombardi G,et al.Muscle,bone,and fat crosstalk:the biological role of myokines,osteokines,and adipokines[J]. Curr Osteoporos Rep,2020,18:388-400.
[24]Park HS,Kim HC,Zhang D,et al.The novel myokine irisin:clinical implications and potential role as a biomarker for sarcopenia in postmenopausal women[J]. Endocrine,2019,64:341-348.
[25]Colaianni G,Faienza MF,Sanesi L,et al.Irisin serum levels are positively correlated with bone mineral status in a population of healthy children[J]. Pediatr Res,2019,85:484-488.
[26]孙顺昌, 彭运生, 贺敬波,等. siRNA阻断鼠成肌细胞myostatin表达对细胞增殖及分化能力的影响[J].基础医学与临床, 2011,31:187-191.