GSDMD是细胞焦亡的关键蛋白

基础医学与临床 ›› 2019, Vol. 39 ›› Issue (6): 895-898.

GSDMD是细胞焦亡的关键蛋白

黄威,程忠平

同济大学附属杨浦区中心医院

收稿日期:2018-06-25 修回日期:2018-10-31 出版日期:2019-06-05 发布日期:2019-06-04
通讯作者: 程忠平 E-mail:mdcheng18@tongji.edu.cn
基金资助:
上海市重点医学专科建设计划任务书

GSDMD is a key protein in the pyroptosis

Received:2018-06-25 Revised:2018-10-31 Online:2019-06-05 Published:2019-06-04

摘要/Abstract

摘要： 细胞焦亡是一种新的细胞死亡模式，该模式不仅能通过依赖于模式识别受体来识别内源性危险信号、病原微生物及其产物刺激炎性小体的作用来激活caspase-1/4/5/11作用于GSDMD；而且使得GSDMD的氨基末端转移至细胞膜上形成的孔隙能允许水分子等物质进入细胞内而引起肿胀及裂解而导致细胞死亡。然而，在细胞焦亡的过程中，关于GSDMD在该过程中的作用以及在相关疾病、肿瘤中的作用仍是个谜。因此，这篇综述的目的是强调了GSDMD引起的焦亡在相关疾病及肿瘤中的作用。

关键词: 细胞焦亡, GsderminD, 细胞肿胀, Caspase-1/4/5/11

Abstract: The pyroptosis is a new model of cell death . This pattern not only activates caspase-1/4/5/11 on GSDMD by relying on pattern recognition receptors to recognize endogenous dangerous signals and the role of pathogenic microorganisms and their products in stimulating inflammatory bodies；but also it makes GSDMD-NT transfer to the cell membrane to form pores that allows water molecules and other substances to enter the cell and cause cell swelling and cleavage. However, in pyroptosis，the role of GSDMD and its role in diseases and tumours remains a mystery.So,the review is to highlight the role of GSDMD that it can lead to pyroptosis in diseases and tumours.

Key words: Pyroptosis, GsderminD, Cell swelling , Caspase-1/4/5/11

黄威程忠平. GSDMD是细胞焦亡的关键蛋白[J]. 基础医学与临床, 2019, 39(6): 895-898.