关键词: 血清尿酸, 高血压, 观察性研究

Abstract: Objective To explore the association between serum uric acid and hypertension in Chinese population. Methods A total of 22 983 individuals (10 787 males and 12 796 females) were collected from 2007 to 2011 derived from the Chinese Physiological Constant and Health Condition (CPCHC) survey and were divided into hypertension group and non-hypertension group according to whether they had hypertension or not. Physical examination and biochemical tests were performed in both groups. Mann-Whitney U test was used to compare the two groups. Chi- square test was used to compare the two groups. Results The prevalence of total hyperuricemia was 13.0% (2977/20006), the prevalence of HUA in hypertension group was much higher than non-hypertension group (18.3% vs 11.2%，P<0.05). The prevalence of hypertension in HUA group was significantly higher than in non-HUA group (male: 38.2% vs 26.0%, P <0.05; female: 37.4% vs 20.2%, P <0.05). The prevalence of HUA in hypertension group was significantly higher than that in non-hypertension group by age, and the prevalence of HUA increased with age after 45 years in both groups. The prevalence of HUA in Han, Hui, Mongolia, North Korea, Tibet, Tujia and other ethnic groups was significantly higher than non-hypertension group. Conclusion Serum uric acid levels is potentially related to the prevalence of hypertension.

Key words: serum uric acid, hypertension, observation study