转录调节因子FOXN1异常表达引起相关疾病的研究进展

基础医学与临床 ›› 2019, Vol. 39 ›› Issue (2): 264-267.

转录调节因子FOXN1异常表达引起相关疾病的研究进展

何啸,胡雨萌,宋银宏

三峡大学医学院

收稿日期:2018-06-14 修回日期:2018-09-27 出版日期:2019-02-05 发布日期:2019-01-16
通讯作者: 宋银宏 E-mail:syh728@126.com
基金资助:
含穿膜肽重组转录因子FOXN1-TAT对衰老小鼠胸腺重建的作用及其细胞和分子机制的研究

Research progress on the diseases caused by abnormal expression of transcription regulator FOXN1

Xiao He¹, Yin-Hong SONG

Received:2018-06-14 Revised:2018-09-27 Online:2019-02-05 Published:2019-01-16
Contact: Yin-Hong SONG E-mail:syh728@126.com
Supported by:
The study on driving thymic regeneration of the aged mice by a recombinant transcription factor fused with cell-penetrating peptide FOXN1-TAT and the corresponding mechanism of cells and molecules

摘要/Abstract

摘要： 自发现FOXN1缺乏症以来，FOXN1在胸腺发育和皮肤生长中的作用愈来愈受重视。 FOXN1是胸腺上皮和T细胞发育的主要调节因子，是维持胸腺发育、功能和稳态的基础。在皮肤中，FOXN1对角质形成细胞和毛囊细胞的分化起关键作用，但潜在的分子机制仍有待进一步阐明。

关键词: 关键词：FOXN1, TEC, SCID, 相关疾病

Abstract: Since report of FOXN1 deficiency, the function of FOXN1 in thymus and skin has been focused on increasingly. FOXN1 is the critical regulator for the development of thymus epithelial cells which determines the development and maturation of T cells, therefore, FOXN1 is fundamental for thymus development, function, and homeostasis. In the skin, it also plays a pivotal role in keratinocytes and hair follicle cell differentiation, however, the underlying molecular mechanisms are still not fully elucidated.

Key words: Key words: FOXN1, TEC, SCID, related diseases

中图分类号:

R392.9

何啸胡雨萌宋银宏. 转录调节因子FOXN1异常表达引起相关疾病的研究进展[J]. 基础医学与临床, 2019, 39(2): 264-267.

Xiao He Yin-Hong SONG. Research progress on the diseases caused by abnormal expression of transcription regulator FOXN1[J]. Basic & Clinical Medicine, 2019, 39(2): 264-267.