基础医学与临床 ›› 2016, Vol. 36 ›› Issue (7): 1030-1034.
• 短篇综述 • 上一篇
郭晓鹏1,高路2,汪强1,幸兵2
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摘要： 循环肿瘤DNA（ctDNA）检测是一种新兴技术，在胶质瘤的早期诊断、疗效监测以及个体化治疗方案制定中有重要意义。异柠檬酸脱氢酶（IDH）基因突变、表皮生长因子受体vⅢ（EGFRvⅢ）基因突变、O6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）启动子甲基化、染色体杂合性缺失（LOH）是近期胶质瘤ctDNA的研究热点。
关键词: 胶质瘤, 循环肿瘤DNA, 基因突变, 启动子甲基化, 杂合性缺失
Abstract: Circulating tumor DNA (ctDNA), known as an emerging molecular biological technique, plays an increasingly vital role in glioma’s early diagnosis, treatment susceptibility monitoring and individualized treatment plan formulation. The IDH and EGFRvIII mutations, methylation status of promoters of MGMT as well as loss of heterozygosity (LOH) in chromosomes arms 1p, 19q and 10q have become the hot spots of glioma research.
Key words: glioma, circulating tumor DNA, genetic mutation, promoter methylation, loss of heterozygosity
中图分类号:
R739.41
郭晓鹏 高路 汪强 幸兵. 循环肿瘤DNA在胶质瘤研究中的进展[J]. 基础医学与临床, 2016, 36(7): 1030-1034.
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