基础医学与临床 ›› 2012, Vol. 32 ›› Issue (8): 870-874.

• 妊娠糖尿病专题 • 上一篇    下一篇

维生素D与妊娠糖尿病

孔晶1,聂敏2,邢小平3,4   

  1. 1. 中国医学科学院 北京协和医学院 北京协和医院内分泌科
    2. 中国医学科学院北京协和医学院北京协和医院内分泌科
    3.
    4. 中国医学科学院 北京协和医学院 北京协和医院
  • 收稿日期:2012-05-16 修回日期:2012-06-14 出版日期:2012-08-05 发布日期:2012-07-17
  • 通讯作者: 邢小平 E-mail:xingxp@126.com

Vitamin D and Gestational diabetes mellitus

  1. 1.
    2. Department of Endocrinology, Key laboratory of Ministry of Health, PUMC Hospital, CAMS & PUMC
  • Received:2012-05-16 Revised:2012-06-14 Online:2012-08-05 Published:2012-07-17
  • Contact: Xiao-ping XING E-mail:xingxp@126.com

摘要: 维生素D具有广泛的生理作用,近期动物以及人体研究提示维生素D能够改善胰岛素抵抗及胰岛?细胞功能。本文总结了孕期维生素D的代谢状况及其在糖代谢中的作用机制,并综述维生素D与妊娠糖尿病相关性的研究结果。现有研究结果存在不一致性,还需要设计良好的随机对照试验探索补充维生素D能否降低妊娠糖尿病的发生率或改善孕期糖代谢。

Abstract: Vitamin D has a wide range of physiological effects. Many animal and human studies have provided evidence that vitamin D plays an important role in insulin sensitivity and pancreatic ?-cell function. This review summarizes the metabolism and mechanism of vitamin D in pregnancy, also provides an overview of studies available on the relationship between vitamin D and gestational diabetes mellitus (GDM). Conflicting results exists on the role of maternal vitamin D status in GDM currently. Hence, well-designed, placebo-controlled, randomized intervention studies are required to establish a true protective influence of vitamin D on glucose homeostasis in GDM.