葛根素等减轻去卵巢和铅中毒大鼠骨质疏松症

基础医学与临床 ›› 2012, Vol. 32 ›› Issue (7): 831-832.

葛根素等减轻去卵巢和铅中毒大鼠骨质疏松症

李海

右江民族医学院

收稿日期:2011-05-10 修回日期:2011-11-30 出版日期:2012-07-05 发布日期:2012-06-20
通讯作者: 李海 E-mail:lihaiying702@163.com

Puerarin and other reducing lead poisoning or ovariectomized in rats osteoporosis

Received:2011-05-10 Revised:2011-11-30 Online:2012-07-05 Published:2012-06-20

摘要/Abstract

摘要： [摘要] 目的：通过观察葛根素对去卵巢大鼠骨质疏松症和海尔福对铅中毒大鼠骨质疏松症的治疗效果，为中医治疗绝经后骨质疏松症和铅中毒大鼠骨质疏松症提供实验依据。方法: 5月龄健康雌性大白鼠100只，分成5个实验组(每组20只)：(1) 正常对照组（Nomal）；（2）去卵巢模型组(OVX)；（3）铅中毒模型组（PLD）；（4）葛根素+去卵巢组（P+ OVX）；（5）海尔福+铅中毒组（H+PLD），各实验组在第12周取大鼠股骨切片观察骨组织，采血测量血钙、磷、碱性磷酸酶和血红蛋白，数据进行统计学分析。结果：OVX组和PLD组光镜下呈明显骨质疏松病理改变，血钙、磷明显低于Nomal组（P﹤0.01），而血碱性磷酸酶明显高于Nomal组（P﹤0.01）。P+ OVX组和H+PLD组与Nomal组比较，血钙、磷和碱性磷酸酶无显著性差异（P﹥0.05），2个治疗组无明显骨质疏松病理改变。结论：葛根素对去卵巢大鼠的骨质疏松症和海尔福对铅中毒大鼠骨质疏松症都有的良好治疗效果；铅中毒可引起大鼠骨质疏松和红蛋白降低。

关键词: 葛根素, 海尔福, 去卵巢大鼠, 铅中毒, 骨质疏松症。

Abstract: [Abstract] Objective: Through observation of puerarin on osteoporosis in ovariectomized rats and rats with lead poisoning Haierfu on the treatment of osteoporosis, as in Traditional Chinese treatment of osteoporosis and postmenopausal osteoporosis in rats with lead poisoning and provide experimental Basis.. Methods: 5 months old female rats 100, divided into five experimental groups (n = 20): (1) control group (Nomal); (2) to the ovariectomy group (OVX); (3) lead poisoning model group (PLD); (4) OVX + puerarin group (P + OVX); (5) lead poisoning Haierfu + group (H + PLD), the experimental group at 12 weeks observed from rat femur bone tissue biopsy, blood Measuring serum calcium, phosphorus and alkaline phosphatase, the data were statistically analyzed.. Results: OVX group and the PLD group showed a light microscope, the pathological changes of osteoporosis, calcium, phosphorus was significantly lower than Nomal group (P <0.01), while the ALP was significantly higher than Nomal group (P <0.01). P + OVX group and the H + PLD group compared with the Nomal calcium, phosphorus, and alkaline phosphatase were no significant differences (P> 0.05), 2 treatment groups had no significant pathological changes of osteoporosis. Conclusion: Puerarin on ovariectomized rats osteoporosis and Haierfu on osteoporosis in rats of lead poisoning have a good therapeutic effect; lead poisoning can cause osteoporosisAnd reduced hemoglobin

Key words: Puerarin, Haierfu, ovariectomized rats, Lead poisoning, Osteoporosis

李海. 葛根素等减轻去卵巢和铅中毒大鼠骨质疏松症[J]. 基础医学与临床, 2012, 32(7): 831-832.

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