关键词: 喉癌, 微小RNA, 肿瘤标志物, 治疗靶点

Abstract: Laryngeal carcinoma is one of the most common cancers in otolaryngology-head and neck surgery. However, its pathogenesis is unclear. Studies have shown that microRNAs (miRNAs) play an important role in the carcinogenesis of laryngeal carcinoma. The abnormal expressions of miRNAs (such as upexpression of miR-106b-25 and miR-21 etc., downexpression of miR-375 and let-7a etc.) are related with the occurrence of laryngeal carcinoma. The abnormal expressed miRNAs in laryngeal carcinoma tissues can be used as tumor markers in the diagnosis of laryngeal carcinoma. Furthermore, some miRNAs may be used as targets for the treatment of laryngeal carcinoma.

Key words: laryngeal carcinoma, microRNA, tumor marker, treatment target