干扰素调节因子4(IRF4)在慢性炎性疾病中作用的研究进展

doi:10.16352/j.issn.1001-6325.2022.07.1119

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (7): 1119-1123.doi: 10.16352/j.issn.1001-6325.2022.07.1119

干扰素调节因子4(IRF4)在慢性炎性疾病中作用的研究进展

栾格^1,2, 王明^1,2, 王成硕^1,2*, 张罗^1,2,3*

首都医科大学附属北京同仁医院 1.耳鼻咽喉头颈外科耳鼻咽喉头颈科学教育部重点实验室(首都医科大学);3.变态反应科, 北京 100730;
2.北京市耳鼻咽喉科研究所鼻病研究北京市重点实验室, 北京 100005

收稿日期:2021-01-26 修回日期:2021-07-12 出版日期:2022-07-05 发布日期:2022-06-29
通讯作者: * dr.luozhang@139.com;wangcs830@126.com
基金资助:
教育部长江学者及创新团队发展计划(IRT13082);国家自然科学基金重点项目(81630023);国家自然科学基金重点国际合作研究项目(81420108009);国家自然科学基金(81870698);国家自然科学基金青年科学基金(81800882,81400444);北京市自然科学基金(7172053)

Research advances in the role of interferon regulatory factor 4(IRF4) in chronic inflammatory diseases

LUAN Ge^1,2, WANG Ming^1,2, WANG Cheng-shuo^1,2*, ZHANG Luo^{1,2, 3*}

1. Department of Otolaryngology Head and Neck Surgery, Key Laboratory of Otolaryngology Head and Neck Surgery of Ministry of Education; 3. Department of Allergology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730;
2. Beijing Institute of Otolaryngology, Beijing Key Laboratory of Nasal Diseases, Beijing 100005, China

Received:2021-01-26 Revised:2021-07-12 Online:2022-07-05 Published:2022-06-29
Contact: * dr.luozhang@139.com;wangcs830@126.com

摘要/Abstract

摘要： 干扰素调节因子4(IRF4)在多种免疫细胞中表达并参与调节多种免疫反应。IRF4与机体多种慢性炎性疾病以及呼吸道过敏性疾病相关,抑制IRF4的表达或功能,可以达到减轻或延缓疾病发生发展的作用。研究IRF4在慢性鼻病和气道过敏性疾病中的作用与机制有助于为疾病治疗提供新思路。

关键词: 干扰素调节因子4, 慢性炎性疾病, 呼吸道过敏性疾病, 免疫调控

Abstract: Interferon regulatory factor 4 (IRF4) is expressed in a variety of immune cells and participates in the regulation of a variety of immune responses. IRF4 is related to a variety of chronic inflammatory diseases and respiratory allergic diseases. Inhibiting the expression or the function of IRF4 can reduce or delay the occurrence and development of the disease. Studying the role and mechanism of IRF4 in chronic rhinopathy and airway allergic diseases will help provide new strategies for disease treatment.

Key words: interferon regulatory factor 4, chronic inflammatory disease, respiratory allergic disease, immune regulation

中图分类号:

R392

栾格, 王明, 王成硕, 张罗. 干扰素调节因子4(IRF4)在慢性炎性疾病中作用的研究进展[J]. 基础医学与临床, 2022, 42(7): 1119-1123.

LUAN Ge, WANG Ming, WANG Cheng-shuo, ZHANG Luo. Research advances in the role of interferon regulatory factor 4(IRF4) in chronic inflammatory diseases[J]. Basic & Clinical Medicine, 2022, 42(7): 1119-1123.

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干扰素调节因子4(IRF4)在慢性炎性疾病中作用的研究进展

Research advances in the role of interferon regulatory factor 4(IRF4) in chronic inflammatory diseases

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