胆红素在炎性肠病中作用的研究进展

doi:10.16352/j.issn.1001-6325.2022.12.1925

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (12): 1925-1929.doi: 10.16352/j.issn.1001-6325.2022.12.1925

胆红素在炎性肠病中作用的研究进展

师丽^1,2, 袁浩², 刘敏², 郑亚², 王玉平², 郭庆红^2*

1.兰州大学第一临床医学院,甘肃兰州 730030;
2.兰州大学第一医院消化科甘肃省胃肠病重点实验室, 甘肃兰州 730030

收稿日期:2021-07-13 修回日期:2021-12-13 出版日期:2022-12-05 发布日期:2022-11-23
通讯作者: ^* guoza@sohu.com
基金资助:
国家自然科学基金(81960430);甘肃省自然科学基金(21JR1RA117);兰州大学第一医院院内基金(ldyyyn2018-38,ldyyyn2018-54)

Research progress on the role of bilirubin in inflammatory bowel disease

SHI Li^1,2, YUAN Hao², LIU Min², ZHENG Ya², WANG Yu-ping², GUO Qing-hong^2*

1. the First Clinical Medical School, Lanzhou University, Lanzhou 730030;
2. Department of Gastroenterology, Key Laboratory of Gastrointestinal Diseases of Gansu Province, the First Hospital of Lanzhou University, Lanzhou 730030, China

Received:2021-07-13 Revised:2021-12-13 Online:2022-12-05 Published:2022-11-23
Contact: ^* guoza@sohu.com

摘要/Abstract

摘要： 胆红素在炎性肠病中的作用不仅仅局限于抗氧化、抗炎作用,还有免疫调节、抗血小板聚集、抑制消化蛋白酶、调节肠道菌群等作用。血清胆红素水平与疾病的活动性、严重程度相关,是炎性肠病潜在的血清标志物,有助于临床炎性肠病诊治。

关键词: 胆红素, 炎性肠病, 克罗恩病, 溃疡性结肠炎

Abstract: The role of bilirubin in inflammatory bowel disease is not only functioned as an antioxidant and anti-inflammatory factor, but also functioned in immune regulation, anti-platelet aggregation, and as inhibition factor of digestive protease and remodeling of microbiota. Serum bilirubin level is correlated with disease activity and severity, so is a potential serum marker of inflammatory bowel disease in terms of supporting clinical diagnosis and treatment of inflammatory bowel disease.

Key words: bilirubin, inflammatory bowel disease, Crohn disease, ulcerative colitis

中图分类号:

R574.6

师丽, 袁浩, 刘敏, 郑亚, 王玉平, 郭庆红. 胆红素在炎性肠病中作用的研究进展[J]. 基础医学与临床, 2022, 42(12): 1925-1929.

SHI Li, YUAN Hao, LIU Min, ZHENG Ya, WANG Yu-ping, GUO Qing-hong. Research progress on the role of bilirubin in inflammatory bowel disease[J]. Basic & Clinical Medicine, 2022, 42(12): 1925-1929.

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胆红素在炎性肠病中作用的研究进展

Research progress on the role of bilirubin in inflammatory bowel disease

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