基础医学与临床 ›› 2022, Vol. 42 ›› Issue (1): 154-158.

• 短篇综述 • 上一篇    下一篇

人体生理参数参考区间的制定方法和应用

何慧婧1,单广良2   

  1. 1. 中国医学科学院基础医学研究所
    2. 中国医学科学院基础医学研究所 北京协和医学院基础学院
  • 收稿日期:2020-11-12 修回日期:2021-04-01 出版日期:2022-01-05 发布日期:2022-01-05
  • 通讯作者: 单广良 E-mail:guangliang_shan@163.com
  • 基金资助:
    科技部基础性工作专项;北京市自然科学基金;国家自然科学基金

Methodology and application of human physiological reference intervals estimation

1,   

  • Received:2020-11-12 Revised:2021-04-01 Online:2022-01-05 Published:2022-01-05
  • Supported by:
    he Key Basic Research Program of the Ministry of Science and Technology of China;Beijing Natural Science Foundation;National Natural Science Foundation of China

摘要: 生理参数参考区间估计对于健康评估、疾病筛查与诊断,以及治疗效果评价具有指导意义。目前中国尚无生理参数参考区间估计的方法学综述。本文拟通过对参考区间估计方法学的系统梳理,系统介绍生理参数参考区间制定的意义、方法和应用。参考区间估计方法主要有3类:非参数法、参数法和稳健估计法。研究者需结合研究目的和数据特点进行选择。本文可为制定生理参数参考区间提供方法学参考,也为实际工作中如何客观合理解读生理参数区间提供指导。

关键词: 参考区间, 生理参数, 方法学, 综述

Abstract: Establishment of physiological reference intervals (RIs) is important for health status evaluation, disease screening and diagnosis,and the effect assessment of clinical therapy. Currently, there is no review on methodology of RI establishment in China. Therefore, by reviews of literatures on methodology of RI establishment, this study aimed to give a comprehensive description on the purpose and significance of RI establishment and its statistical methods of calculation, as well as its application. Three methods are commonly used for RI calculation: the nonparametric, parametric and robust estimate. Researchers could choose a specific method or methods based on their purpose and the characteristics of the data. This review could provide methodological reference for RI establishment in China, and also guidelines to better understand the meaning of physiological constant RIs in health practices.

Key words: Reference interval, Physiological constants, Methodology, Review