基础医学与临床 ›› 2022, Vol. 42 ›› Issue (1): 149-153.

• 短篇综述 • 上一篇    下一篇

结肠炎诱发肝脏屏障功能障碍的研究进展

树梦萱1,2,袁方晨1,2,周梦琪1,2,涂世盐1,2,许玥1,2,秦红岩2   

  1. 1. 兰州大学第一临床医学院
    2. 兰州大学第一医院
  • 收稿日期:2020-08-14 修回日期:2021-01-07 出版日期:2022-01-05 发布日期:2022-01-05
  • 通讯作者: 秦红岩 E-mail:1079084341@qq.com
  • 基金资助:
    国家自然科学基金;兰州大学中央高校基本科研专项资金;兰州大学大学生创新创业行动计划项目;兰州大学第一临床医学院“卓越计划”学生科研创新培育项目

Research progress in colitis-induced hepatic barrier dysfunction

  • Received:2020-08-14 Revised:2021-01-07 Online:2022-01-05 Published:2022-01-05
  • Contact: Hongyan Qin E-mail:1079084341@qq.com

摘要: 肝脏屏障是肝脏抵御外源性有害物质侵袭的主要结构,在维持肝脏分泌功能,调控胆汁转运及细胞间信息传递中发挥重要作用。内毒素、炎性因子及胆汁酸等诱发肝脏屏障蛋白改变及屏障功能障碍,可能参与结肠炎性肝病发生。探究结肠炎对肝脏屏障的影响及机制,从肝脏屏障角度阐释结肠炎性肝病的发生机制有望为其防治提供线索和依据。

关键词: 结肠炎, 肝脏屏障, 内毒素, 胆汁酸, 炎性因子

Abstract: Liver barrier, the main structure to protect the liver from exogenous harmful substances, plays an important role in maintaining secretion function, regulating bile transport and intercellular information transmission. Liver barrier protein alteration and barrier dysfunction can be induced by endotoxin, inflammatory cytokines and bile acids, which may be involved in the occurrence of colitis-related liver diseases. To explore the effect and underlying mechanism of intestinal inflammation on liver barrier function may explain the pathogenesis of colitis-related liver diseases, and thus provide clues and basic information for its prevention and treatment.

Key words: colitis, liver barrier, endotoxin, bile acids, inflammatory cytokines