基础医学与临床 ›› 2021, Vol. 41 ›› Issue (9): 1347-1351.

• 短篇综述 • 上一篇    下一篇

N6-甲基腺苷(m6A)RNA修饰在生殖系统疾病中作用的研究进展

张妍, 朱孟雯, 刘桐, 杨圣, 梁戈玉*   

  1. 东南大学 公共卫生学院 环境医学工程教育部重点实验室,江苏 南京 210009
  • 收稿日期:2020-07-30 修回日期:2020-11-17 出版日期:2021-09-05 发布日期:2021-09-02
  • 通讯作者: *lianggeyu@163.com
  • 基金资助:
    国家自然科学基金(81972998)

Research progress on the role of N6-methyladenosine (m6A) RNA modification in reproductive system diseases

ZHANG Yan, ZHU Meng-wen, LIU Tong, YANG Sheng, LIANG Ge-yu*   

  1. Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China
  • Received:2020-07-30 Revised:2020-11-17 Online:2021-09-05 Published:2021-09-02
  • Contact: *lianggeyu@163.com

摘要: N6-甲基腺苷(m6A)RNA修饰是发生在RNA腺嘌呤第6位N原子上的一种转录后的甲基化修饰,调控mRNA的结构、稳定性、剪接、输出、转译和衰变等,进而广泛影响各种生物的生命过程。本文总结了在生殖系统疾病及乳腺癌发生发展过程中各种m6A甲基化酶的作用及机制,旨在为生殖系统疾病及乳腺癌早期诊断、治疗及预后判断提供新的依据。

关键词: N6-甲基腺苷(m6A), 生殖系统疾病, 表观遗传, 乳腺癌

Abstract: N6-methyladenosine (m6A) RNA modification is a post-transcriptional modification occurring on the 6th N atom of RNA adenine (A), regulating the structure, stability, splicing, output, translation and decay of mRNA, and thus extensively affecting the life processes of various organisms.This paper summarized the role and mechanism of various m6A methylase in the occurrence and development of reproductive system diseases and breast caner, in order to provide new basis for early diagnosis, treatment and improved prognosis of reproductive system diseases and breast caner.

Key words: N6-methyladenosine(m6A), reproductive system diseases, epigenetics, breast cancer

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