表观遗传调控在阻塞性睡眠呼吸暂停综合征中的作用研究进展

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (6): 899-903.

表观遗传调控在阻塞性睡眠呼吸暂停综合征中的作用研究进展

陈凤, 冷玉芳^*, 任以行, 张健民, 刘馨, 石亚静

兰州大学第一临床医学院, 甘肃兰州 730000

收稿日期:2020-07-07 修回日期:2020-08-14 出版日期:2021-06-05 发布日期:2021-05-31
通讯作者: ^*lengyf@lzu.edu.cn
基金资助:
国家自然科学基金(81960345)

Research progress on the role of epigenetic regulation in obstructive sleep apnea syndrome

CHEN Feng, LENG Yu-fang^*, REN Yi-xing, ZHANG Jian-min, LIU Xin, SHI Ya-jing

the First Clinical Medical College, Lanzhou University, Lanzhou 730000, China

Received:2020-07-07 Revised:2020-08-14 Online:2021-06-05 Published:2021-05-31
Contact: ^*lengyf@lzu.edu.cn

摘要/Abstract

摘要： 慢性间歇性低氧在阻塞性睡眠呼吸暂停综合征(OSA)的各种不良反应的发生机制中发挥重要作用。表观遗传过程通过影响慢性间歇性低氧条件下的适应潜能和表型变异,参与OSA及并发症的发生和发展。所以,了解表观遗传调控对OSA的作用有助于为OSA的临床表型和靶向治疗提供新的思路。

关键词: 阻塞性睡眠呼吸暂停, 表观遗传学, DNA甲基化, 组蛋白修饰, 非编码RNA

Abstract: Chronic intermittent hypoxia plays an important role in the mechanism of various adverse reactions of obstructive sleep apnea syndrome (OSA). Epigenetic process participates in the occurrence and development of OSA and complications by affecting adaptive potential and phenotypic variation under chronic intermittent hypoxia. Therefore, understanding the effect of epigenetic regulation on OSA is helpful to provide new ideas for clinical phenotype and targeted therapy of OSA.

Key words: obstructive sleep apnea, epigenetic, DNA methylation, histone modification, non-coding RNA

中图分类号:

Q39
R563.9

陈凤, 冷玉芳, 任以行, 张健民, 刘馨, 石亚静. 表观遗传调控在阻塞性睡眠呼吸暂停综合征中的作用研究进展[J]. 基础医学与临床, 2021, 41(6): 899-903.

CHEN Feng, LENG Yu-fang, REN Yi-xing, ZHANG Jian-min, LIU Xin, SHI Ya-jing. Research progress on the role of epigenetic regulation in obstructive sleep apnea syndrome[J]. Basic & Clinical Medicine, 2021, 41(6): 899-903.

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