认知衰弱诊治的研究进展

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (6): 895-898.

认知衰弱诊治的研究进展

赵瑞雪¹, 马雅军¹, 刘惠¹, 李晓东¹, 王笑峰², 蒋晓燕³, 李淑娟^1*

1.首都医科大学附属北京朝阳医院神经内科, 北京 100020;
2.复旦大学人类表型组研究院现代人类学教育部重点实验室,上海 200433;
3.同济大学医学院病理学与病理生理学系,上海 200092

收稿日期:2020-06-01 修回日期:2020-08-29 出版日期:2021-06-05 发布日期:2021-05-31
通讯作者: ^*2431965@qq.com
基金资助:
国家重点研发计划项目(2018YFC2000400,2018YFC2002000);国家自然科学基金(81971102)

Progress in the diagnosis and treatment of cognitive frailty

ZHAO Rui-xue¹, MA Ya-jun¹, LIU Hui¹, LI Xiao-dong¹, WANG Xiao-feng², JIANG Xiao-yan³, LI Shu-juan^1*

1. Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020;
2. Ministry of Education Key Laboratory of Contemporary Anthropology, Human Phenome Institute, Fudan University, Shanghai 200433;
3. Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai 200092,China

Received:2020-06-01 Revised:2020-08-29 Online:2021-06-05 Published:2021-05-31
Contact: ^*2431965@qq.com

摘要/Abstract

摘要： 认知衰弱是一种同时存在身体衰弱和认知损害而使痴呆风险增加的老年综合征,与功能性残疾、住院、跌倒和全因死亡等不良健康事件及痴呆、血管性痴呆、神经认知障碍的发生相关,具有潜在的可逆性。未来制定明确统一的认知衰弱操作性定义,对于早期识别、干预认知衰弱,以及痴呆早期或无症状阶段的二级预防具有重要意义。

关键词: 认知衰弱, 身体衰弱, 认知障碍, 衰弱模型, 不良健康事件

Abstract: Cognitive frailty, which increases the risk of dementia, is a geriatric syndrome characterized by both physical frailty and cognitive impairment. It is associated with adverse health events such as functional disability, hospitalization, falls, all-cause mortality and the incidence of dementia, vascular dementia, neurocognitive disorders, with potential reversibility. A clear and unified operational definition of cognitive frailty in the future is of great significance for early recognition and intervention of cognitive frailty and secondary prevention of early or asymptomatic dementia.

Key words: cognitive frailty, physical frailty, cognitive dysfunction, frailty models, adverse health events

中图分类号:

R741

赵瑞雪, 马雅军, 刘惠, 李晓东, 王笑峰, 蒋晓燕, 李淑娟. 认知衰弱诊治的研究进展[J]. 基础医学与临床, 2021, 41(6): 895-898.

ZHAO Rui-xue, MA Ya-jun, LIU Hui, LI Xiao-dong, WANG Xiao-feng, JIANG Xiao-yan, LI Shu-juan. Progress in the diagnosis and treatment of cognitive frailty[J]. Basic & Clinical Medicine, 2021, 41(6): 895-898.

参考文献

[1] De Biasio JC, Mittel AM, Mueller AL, et al. Frailty in critical care medicine: a review[J]. Anesth Analg, 2020, 130: 1462-1473.
[2] Feng L, Zin Nyunt MS, Gao Q, et al. Cognitive frailty and adverse health outcomes: findings from the Singapore Longitudinal Ageing Studies (SLAS)[J]. J Am Med Dir Assoc, 2017, 18: 252-258.
[3] Niederstrasser NG, Rogers NT, Bandelow S. Determinants of frailty development and progression using a multidimensional frailty index: evidence from the English Longitudinal Study of Ageing[J]. PLoS One, 2019, 14: e0223799.doi: 10.1371/journal.pone.0223799.
[4] Panza F, Lozupone M, Solfrizzi V, et al. Different cognitive frailty models and health- and cognitive-related outcomes in older age: from epidemiology to prevention[J]. J Alzheimers Dis, 2018, 62: 993-1012.
[5] Kelaiditi E, Cesari M, Canevelli M, et al. Cognitive frailty: rational and definition from an (I.A.N.A./I.A.G.G.) international consensus group[J]. J Nutr Health Aging, 2013, 17: 726-734.
[6] Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype[J]. J Gerontol A Biol Sci Med Sci, 2001, 56: M146-156.
[7] Rockwood K, Song X, MacKnight C, et al. A global clinical measure of fitness and frailty in elderly people[J]. Cmaj, 2005, 173: 489-495.
[8] Gobbens RJ, van Assen MA, Luijkx KG, et al. Testing an integral conceptual model of frailty[J]. J Adv Nurs, 2012, 68: 2047-2060.
[9] Facal D, Maseda A, Pereiro AX, et al. Cognitive frailty: a conceptual systematic review and an operational proposal for future research[J]. Maturitas, 2019, 121: 48-56.
[10] Xie B, Larson JL, Gonzalez R, et al. Components and indicators of frailty measures: a literature review[J]. J Frailty Aging, 2017, 6: 76-82.
[11] Sargent L, Brown R. Assessing the current state of cognitive frailty: measurement properties[J]. J Nutr Health Aging, 2017, 21: 152-160.
[12] Solfrizzi V, Scafato E, Lozupone M, et al. Additive role of a potentially reversible cognitive frailty model and inflammatory state on the risk of disability: the Italian Longitudinal Study on Aging[J]. Am J Geriatr Psychiatry, 2017, 25: 1236-1248.
[13] Roppolo M, Mulasso A, Rabaglietti E. Cognitive frailty in Italian community-dwelling older adults: prevalence rate and its association with disability[J]. J Nutr Health Aging, 2017, 21: 631-636.
[14] Solfrizzi V, Scafato E, Seripa D, et al. Reversible cognitive frailty, dementia, and all-cause mortality:the Italian Longitudinal Study on Aging[J]. J Am Med Dir Assoc, 2017, 18: 89.e81-89.e88.
[15] Kim H, Awata S, Watanabe Y, et al. Cognitive frailty in community-dwelling older Japanese people: prevalence and its association with falls[J]. Geriatr Gerontol Int, 2019, 19: 647-653.
[16] Picca A, Coelho-Junior HJ, Cesari M, et al. The metabolomics side of frailty: toward personalized medicine for the aged[J]. Exp Gerontol, 2019, 126: 110692.doi: 10.1016/j.exger.2019.110692.
[17] Montero-Odasso MM, Barnes B, Speechley M, et al. Disentangling cognitive-frailty: results from the Gait and Brain Study[J]. J Gerontol A Biol Sci Med Sci, 2016, 71: 1476-1482.
[18] Feng L, Nyunt MS, Gao Q, et al. Physical frailty, cognitive impairment, and the risk of neurocognitive disorder in the Singapore Longitudinal Ageing Studies[J]. J Gerontol A Biol Sci Med Sci, 2017, 72: 369-375.
[19] Kueper JK, Speechley M, Lingum NR, et al. Motor function and incident dementia: a systematic review and meta-analysis[J]. Age Ageing, 2017, 46: 729-738.
[20] Panza F, Lozupone M, Solfrizzi V, et al. Cognitive frailty: a potential target for secondary prevention of dementia[J]. Expert Opin Drug Metab Toxicol, 2017, 13: 1023-1027.
[21] Jansen-Kosterink S, van Velsen L, Frazer S, et al. Identification of community-dwelling older adults at risk of frailty using the PERSSILAA screening pathway: a methodological guide and results of a large-scale deployment in the Netherlands[J]. BMC Public Health, 2019, 19: 504. doi: 10.1186/s12889-019-6876-0.
[22] Zugasti Murillo A, Casas Herrero Á. Frailty syndrome and nutritional status: assessment, prevention and treatment.[J]. Nutr Hosp, 2019, 36: 26-37.
[23] Macdonald SH, Travers J, Shé ÉN, et al. Primary care interventions to address physical frailty among community-dwelling adults aged 60 years or older: a meta-analysis[J]. PLoS One, 2020, 15: e0228821.doi: 10.1371/journal.pone.0228821.
[24] Dominguez LJ, Barbagallo M. The relevance of nutrition for the concept of cognitive frailty[J]. Curr Opin Clin Nutr Metab Care, 2017, 20: 61-68.
[25] Ntanasi E, Yannakoulia M, Kosmidis MH, et al. Adherence to mediterranean diet and frailty[J]. J Am Med Dir Assoc, 2018, 19: 315-322.