基础医学与临床 ›› 2021, Vol. 41 ›› Issue (5): 661-666.

• 研究论文 • 上一篇    下一篇

基于DWI的对消岩汤联合GC化学药物治疗晚期非小细胞肺癌疗效的预测价值

韩燕*, 官丙奇, 周刚, 马菲   

  1. 天津市中医药研究院附属医院 放射科, 天津 300020
  • 收稿日期:2020-06-16 修回日期:2020-10-13 出版日期:2021-05-05 发布日期:2021-05-06
  • 通讯作者: *wangyi56321you@163.com
  • 基金资助:
    国家自然科学基金(81503675)

Predictive value of Xiaoyan decoction combined with GC chemotherapy in the treatment of advanced non-small cell lung cancer based on DWI

HAN Yan*, GUAN Bing-qi, ZHOU Gang, MA Fei   

  1. Department of Radiology, Affiliated Hospital of Tianjin Institute of Traditional Chinese Medicine, Tianjin 300020, China
  • Received:2020-06-16 Revised:2020-10-13 Online:2021-05-05 Published:2021-05-06
  • Contact: *wangyi56321you@163.com

摘要: 目的 探讨消岩汤联合吉西他滨/卡铂(GC)化学药物治疗晚期非小细胞肺癌(NSCLC)的预测价值。方法 回顾性分析65例接受消岩汤联合GC化学药物治疗的晚期NSCLC患者临床资料,比较有效组和无效组治疗前和后磁共振扩散加权成像(DWI)表观扩散系数(ADCpre和ADCpost)及ADC变化率(ΔADC),分析ADCpre、ADCpost及ΔADC与肿瘤消退率的相关性及对疗效的预测价值。结果 消岩汤联合GC化学药物治疗有效率为58.46%。治疗前DWI均表现为高信号,ADCpre较低;治疗后DWI以等信号为主,ADCpost较高。肿瘤消退率与ADCpre负相关,与ADCpost和ΔADC正相关(P<0.05)。ADCpre预测疗效的灵敏度、特异度、准确度和AUC分别为71.05%、81.48%、75.38%、0.789;ADCpost为89.47%、66.67%、80.00%、0.810;ΔADC为81.58%、85.19%、83.08%、0.842。结论 晚期NSCLC患者ADCpre、ADCpost及ΔADC与肿瘤消退率关系密切,DWI能够较好预测消岩汤联合GC化学药物治疗的临床疗效。

关键词: 非小细胞肺癌, 磁共振扩散加权成像(DWI), 临床疗效, 预测

Abstract: Objective To explore the predictive value for the efficacy of Xiaoyan decoction combined with gemcitabine/carboplatin (GC) chemotherapy in the treatment of advanced non-small cell lung cancer (NSCLC). Methods The clinical data from 65 patients with advanced NSCLC who were treated with Xiaoyan decoction and GC chemotherapy were analyzed retrospectively. The apparent diffusion coefficient before and after treatment (ADCpre and ADCpost) of magnetic resonance diffusion-weighted imaging (DWI) and ADC change rate (ΔADC) were compared between the effective group and the ineffective group. The correlation of ADCpre and ADCpost and ΔADC with tumor regression rate and their predictive value for curative effect were analyzed. Results The effective rate of Xiaoyan decoction combined with GC chemotherapy was 58.46%. Before treatment, DWI showed a high signal, ADCpre was low, and DWI was mainly equal signal and ADCpost was high after treatment. The tumor regression rate was negatively correlated with ADCpre, and positively correlated with ADCpost and ΔADC(P<0.05). The sensitivity, specificity, accuracy and AUC of ADCpre for efficacy prediction were 71.05%, 81.48%,75.38%, 0.789, respectively, and ADCpost was 89.47%, 66.67%, 80.00%, 0.810, and ΔADC was 81.58%, 85.19%, 83.08%, 0.842. Conclusions ADCpre, ADCpost and ΔADC are closely related to tumor regression rate in advanced NSCLC patients. DWI can predict the clinical efficacy of Xiaoyan decoction combined with GC chemotherapy.

Key words: non-small cell lung cancer, diffusion-weighted imaging(DWI), clinical efficacy, prediction

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