基础医学与临床 ›› 2021, Vol. 41 ›› Issue (11): 1643-1647.

• 临床研究 • 上一篇    下一篇

厦门地区3 144例女性人乳头瘤病毒(HPV)感染及宫颈病变筛查分析

许惠娟, 刘坤, 郑景妹, 姜秋利, 鲁华东, 许建芳*   

  1. 复旦大学附属中山医院厦门医院 病理科, 福建 厦门 361015
  • 收稿日期:2021-04-20 修回日期:2021-09-17 发布日期:2021-10-27
  • 通讯作者: *xu.jianfang@zs-hospital.sh.cn
  • 基金资助:
    厦门市科技计划项目(3502Z20184003)

Human papilloma virus (HPV) infection and cervical lesions screened in 3 144 women at Xiamen, Fujian province, China

XU Hui-juan, LIU Kun, ZHENG Jing-mei, JIANG Qiu-li, LU Hua-dong, XU Jian-fang*   

  1. Department of Pathology, Zhongshan Hospital, Fudan University(Xiamen Branch),Xiamen 361015, China
  • Received:2021-04-20 Revised:2021-09-17 Published:2021-10-27
  • Contact: *xu.jianfang@zs-hospital.sh.cn

摘要: 目的 分析宫颈癌筛查妇女中人乳头瘤病毒(HPV)感染状况及其与宫颈病变之间的关系。方法 采集2019年5月至2020年6月在复旦大学附属中山医院厦门医院接受宫颈筛查的中国厦门地区3 144例女性宫颈口脱落细胞,通过博晖生物芯片法进行HPV基因分型检测,以及膜式液基薄层细胞学检查法(TCT)进行宫颈细胞学病理检查。结果 3 144例妇女中HPV感染率为22.3%,其中高危型HPV感染率为18.6%,低危型感染率为3.8%。HPV感染率由高到低依次为HPV52、58、16、56、44、42、81、51、53和39。分析5组不同年龄组感染情况,60岁以上年龄组阳性检出率最高,达39.4%,不同年龄组HPV感染情况存在差异(P<0.01)。HPV阳性患者以单一高危型感染较为多见(59.0%),多重感染以双重高危型HPV感染为主(12.2%)。结论 本地区宫颈癌筛查妇女HPV感染亚型分布情况与其他地区有所区别,60岁以上年龄组阳性检出率最高,不同年龄组HPV感染情况有明显差异,HPV感染情况对宫颈组织病变的筛查具有指导意义。

关键词: 人乳头瘤病毒, 宫颈病变, 感染

Abstract: Objective To analyze the status of human papilloma virus (HPV) infection and its correlation with cervical lesions in women screened for cervical cancer. Methods 3 144 women in Xiamen of China metropolitan area received cervical screening in Zhongshan Hospital, Fudan University (Xiamen Branch) from May 2019 to June 2020 were selected as the research subjects. Their cervical exfoliated cells were collected for HPV genotyping by Bohui biochip method, and cervical cytological pathological examination was performed by ThinPrep cytological test operating system. Results The infection rate of HPV in 3 144 women was 22.3%, among which the rate of high risk was 18.6% and the rate of low risk was 3.8%. The top 10 subtypes of HPV infection were type 52,58,16,56,44,42,81,51,53 and 39.According to the analysis of the infection of 5 groups in different age groups, the highest positive detection rate was 39.4% in the age group over 60 years old, and positive rate of HPV infection varied with different age groups (P<0.01). In HPV-positive patients, single high-risk HPV infection was more common (59.0%), and double high-risk HPV infection was the main type of multiple infection (12.2%). Conclusions There are significant differences in HPV infection among different age groups in this area, and this epidemiology evidence may support the policy development of screening cervical tissue lesions.

Key words: human papilloma virus, cervical lesion, infection

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