基础医学与临床 ›› 2021, Vol. 41 ›› Issue (10): 1476-1480.

• 研究论文 • 上一篇    下一篇

脑胶质瘤患者MGMT启动子甲基化和IDH1突变与临床预后相关

张宁1, 马辉辉1*, 王凡1, 梁伟1, 汪义纯1, 吴炳山2, 李庆新2   

  1. 安徽医科大学第一附属医院 1.肿瘤放射治疗科; 2.神经外科,安徽 合肥 230022
  • 收稿日期:2020-11-09 修回日期:2021-01-09 发布日期:2021-09-29
  • 通讯作者: *mahui200@126.com
  • 基金资助:
    中华国际医学交流基金(Z-2014-06-19412)

Correlations of MGMT promoter methylation and IDH1 mutations with the clinical prognosis of malignant glioma patients

ZHANG Ning1, MA Hui-hui1*, WANG Fan1, LIANG Wei1, WANG Yi-chun1, WU Bing-shan2, LI Qing-xin2   

  1. 1. Department of Radiotherapy; 2. Department of Neurosurgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
  • Received:2020-11-09 Revised:2021-01-09 Published:2021-09-29
  • Contact: *mahui200@126.com

摘要: 目的 本研究回顾性分析MGMTIDH1在脑胶质瘤患者中的突变及表达状况,探讨二者共表达与临床预后之间的关系。方法 将放射治疗科2017年10月至2019年10月收治的25例脑胶质瘤术后患者纳入本研究;采用Kaplan-Meier法分析生存率;Log-rank法进行单因素分析。结果 MGMT启动子甲基化患者(χ2=4.22,P<0.05)较非甲基化者的总生存期(OS)明显延长,MGMT甲基化患者较非甲基化患者的疾病无进展生存时间(PFS)、IDH1阳性患者的OS、PFS较阴性患者无明显延长。MGMT甲基化联合IDH1突变患者较MGMT非甲基化联合IDH1无突变患者生存期明显延长 (P<0.05)。结论 脑胶质瘤术后患者的MGMT甲基化及IDH1基因水平与OS、PFS显著相关,是影响患者临床预后的重要因素。

关键词: 胶质瘤, MGMT, IDH1, 突变, 预后

Abstract: Objective To analyze retrospectively the IDH1 mutation and MGMT promoter methylation of malignant glioma patients and to identify potential relation to clinical situation. Methods Twenty-five patients with glioma who were received treatment from October 2017 to October 2019 were selected; the survival rate was calculated by Kaplan-Meier method and analyzed by Log-Rank test. Results Univariate analysis showed that negative status of MGMT gene promoter methylation(χ2=4.22,P<0.05) was an important factor affecting the survival rates of patients, and patients with both negative status of MGMT gene promoter methylation and mutation of IDH1 had a significantly prolonged survival(P<0.05). Conclusions IDH mutation and MGMT promoter methylation status are significantly related to the prognosis of malignant glioma patients.

Key words: glioma, MGMT, IDH1, mutation, prognosis

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