雌性生殖干细胞衰老相关因素及延缓措施的研究进展

基础医学与临床 ›› 2020, Vol. 40 ›› Issue (11): 1546-1550.

雌性生殖干细胞衰老相关因素及延缓措施的研究进展

钟志胜¹, 洪雯丽², 曹秀萍^3,6, 聂坤⁴, 唐子娟^5,6, 谢奇^5,6, 李佳^3,6*

1.深圳市中医院, 广东深圳 518034;
2.遵义医科大学珠海校区, 广东珠海 519041;
3.南昌大学医学实验教学中心;
4.南昌大学第二临床医学院;
5.南昌大学护理学院医学系;
6.江西省生殖生理与病理重点实验室,江西南昌 330006

收稿日期:2019-08-26 修回日期:2020-01-07 出版日期:2020-11-05 发布日期:2020-10-30
通讯作者: ^* lijia4199@163.com
基金资助:
国家自然科学基金(81671455,81771583,31460307);江西省自然科学基金 (20192BAB215009,20142BAB205004);南昌大学医学部青年教师科研培育基金(PY201814)

Research progress on aging related factors and delaying measures for aging of female germ line stem cells

ZHONG Zhi-sheng¹, HONG Wen-li², CAO Xiu-ping^3,6, NIE Kun⁴, TANG Zi-juan^5,6, XIE Qi^5,6, LI Jia^3,6*

1. Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518034;
2. Zunyi Medical University Zhuhai Campus, Zhuhai 519041;
3. Medical Laboratory Education Center;
4. the Second Clinical Medical School;
5. Department of Medicine, School of Nursing;
6. the Key Laboratory of Reproductive Physiology and Pathology of Jiangxi Province, Nanchang University, Nanchang 330006, China

Received:2019-08-26 Revised:2020-01-07 Online:2020-11-05 Published:2020-10-30
Contact: ^* lijia4199@163.com

摘要/Abstract

摘要： 哺乳动物雌性生殖干细胞(FGSCs)因其在卵泡更新及生育能力维持/恢复中的重要作用备受关注,但其衰老机制及其预防措施尚不明确。有研究显示,FGSCs巢内的微环境改变如免疫紊乱、炎性反应和氧化应激等能在相关信号通路和基因的介导下导致FGSCs衰老及数量骤降。故而,调节免疫功能紊乱、抗炎性反应和氧化应激以及调控相关信号通路和基因,有望能延缓FGSCs的衰老。

关键词: 雌性生殖干细胞, 衰老因素, 延缓策略

Abstract: In recent years, female germ line stem cells (FGSCs) in mammals have attracted much attention because of their contribution to follicular renewal and fertility maintenance/restoration, but their aging mechanism and preventive measures are still unclear. Studies have shown that the microenvironment changes in FGSCs nests, such as immune disorder, chronic inflammation and oxidative stress, can lead to the aging and plummeting of FGSCs through the mediation of relevant signaling pathways and genes. Therefore, the regulation of immune dysfunction, anti-inflammation and oxidative stress, and potential intervention to related signaling pathways as well as genes expression are expected to have some effect on slowing down FGSCs aging process.

Key words: female germline stem cells, aging factors, delaying measures

中图分类号:

R339.2

钟志胜, 洪雯丽, 曹秀萍, 聂坤, 唐子娟, 谢奇, 李佳. 雌性生殖干细胞衰老相关因素及延缓措施的研究进展[J]. 基础医学与临床, 2020, 40(11): 1546-1550.

ZHONG Zhi-sheng, HONG Wen-li, CAO Xiu-ping, NIE Kun, TANG Zi-juan, XIE Qi, LI Jia. Research progress on aging related factors and delaying measures for aging of female germ line stem cells[J]. Basic & Clinical Medicine, 2020, 40(11): 1546-1550.

参考文献

[1] Johnson J, Canning J, Kaneko T, et al. Germline stem cellsand follicularrenewal in the postnatal mammalian ovary[J]. Nature, 2004, 428: 145-150.
[2] Valli H, Phillips BT, Shetty G, et al. Germline stem cells: toward the regeneration of spermatogenesis[J]. Fertility Sterility, 2014, 101:3-13.
[3] Martin JJ, Woods DC, Tilly JL. Implications and current limitations of oogenesis from female germline or oogonial stem cells in adult mammalian ovaries[J]. Cells,2019,8:93.doi:10.3390/cells8020093.
[4] Niikura Y, Niikura T, Tilly JL. Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment[J]. Aging,2009, 1: 971-978.
[5] Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell[J]. Blood Cells, 1978, 4:7-25.
[6] Wang X, Page-Mccaw A. Wnt6 maintains anterior escort cells as an integral component of the germline stem cell niche[J]. Development, 2018,145:dev158527.doi:10.1242/dev.158527.
[7] Yangchun L, Jiao X, Feiyin Z,et alet alet al. Research advances in the regulation of the putative ovarian germline stem cell niche on female germline stem cells[J]. Syst Biol Reprod Med,2019,65:121-128.
[8] Massasa E, Costa XS, Taylor HS. Failure of the stem cell niche rather than loss of oocyte stem cells in the aging ovary[J]. Aging, 2010,2:1-2.
[9] Bukovsky A,Presl J. Ovarian function and the immune system[J]. Med Hypotheses,1979,5: 415-436.
[10] Ye HF, Li XY, Zheng TC, et al.The effect of the immune system on ovarian function and features of ovarian germline stem cells[J]. Springer Plus,2016,5:990.doi:10.1186/S40064-016-2390-3.
[11] Komorowska B. Autoimmune premature ovarian failure[J]. Menopause Rev, 2016,15: 210-214.
[12] Signer RAJ, Morrison SJ. Mechanisms that regulate stem cell aging and life span[J]. Cell Stem Cell, 2013, 12:152-165.
[13] Pervaiz S, Taneja R, Ghaffari S. Oxidative stress regula-tion of stem and progenitor cells[J]. Antioxid Redox Signal, 2009, 11:2777-2789.
[14] Wu J, Tu D, Yuan, YL,et al. T-2 toxin exposure induces apoptosis in rat ovarian granulosa cells through oxidative stress[J]. Environ Toxicol Pharmacol, 2013, 36:493-500.
[15] Waghmare I, Page-Mccaw A. Wnt signaling in stem cell maintenance and differentiation in the drosophila germari-um[J]. Genes, 2018, 9: pii: E127.doi:10.3390/genes9030127.
[16] Wang X, Page-McCaw A. A matrix metalloproteinase mediates long-distance attenuation of stem cell proliferation[J]. J. Cell Biol, 2014, 206, 923-936.
[17] Luo L, Siah CK, Cai Y. Engrailed acts with Nejire to control decapentaplegic expression in the Drosophila ovarian stem cell niche[J]. Development, 2017, 144:3224-3231.
[18] Li J, Zhou F, Zheng T, et al. Ovarian germline stem cells (OGSCs) and the hippo signaling pathway association with physiological and pathological ovarian aging in mice[J]. Cell Physiol Biochem, 2015, 36:1712-1724.
[19] Ye H, Li X, Zheng T, et al. The hippo signaling pathway regulates ovarian function via the proliferation of ovarian germline stem cells[J]. Cell Physiol and Biochem, 2017, 41:1051-1062.
[20] Pan Z, Sun M, Li J, et al.The expression of markers related to ovarian germline stem cells in the mouse ovarian surface epithelium and the correlation with notch signaling pathway[J]. Cell Physiol Biochem, 37, 2311-2322.
[21] Yi F, Zheng J, Li Q, et al. Inhibition of chitin oligosaccharide on dyslipidemia and the potential molecular mechanism exploration[J]. J Biotechnol, 2017,33: 630-641.
[22] Yang K, Chan CB. Proposed mechanisms of the effects of proanthocyanidins on glucose homeostasis[J]. Nutrition Reviews, 2017, 75: 642-657.
[23] Liu Y, Tong L, Luo Y, et al. Resveratrol inhibits the proliferation and induces the apoptosis in ovarian cancer cells via inhibiting glycolysis and targeting AMPK/mTOR signaling pathway[J]. J Cell Biochem, 2018, 119: 6162-6172.
[24] Lucchetta EM, Ohlstein B. Amitosis of polyploid cells regenerates functional stem cells in the drosophila Intestine[J]. Cell Stem Cell, 2017, 20:609-620.
[25] Gu ZY, Wu J, Yang XW, et al. STAT3 is required for proliferation and exhibits a cell type-specific binding preference in mouse female germline stem cells[J]. Mol Omics, 2018,14: 95-102.
[26] Yang H, Yao X, Tang F, et al. Characterization of female germline stem cells from adult mouse ovaries and the role of rapamycin on them[J]. Cytotechnology, 2018,70: 843-854.