基础医学与临床 ›› 2019, Vol. 39 ›› Issue (6): 904-907.

• 短篇综述 • 上一篇    下一篇

常见泌尿生殖系统肿瘤的病因学分析及预防

董德鑫1,李汉忠1,纪志刚1,石冰冰2   

  1. 1. 中国医学科学院 北京协和医学院 北京协和医院泌尿外科
    2. 中国医学科学院 北京协和医学院 北京协和医院
  • 收稿日期:2019-01-07 修回日期:2019-04-17 出版日期:2019-06-05 发布日期:2019-06-04
  • 通讯作者: 李汉忠 E-mail:lihzhpumch@163.com

Etiological analysis and prevention of common urological tumors

  • Received:2019-01-07 Revised:2019-04-17 Online:2019-06-05 Published:2019-06-04
  • Contact: LI Han-zhong E-mail:lihzhpumch@163.com

摘要: 采用文献检索和临床病例,探讨泌尿系统肿瘤的病因学分析,明确影响因素。泌尿系统肿瘤的发病原因包含内因(遗传和变异)和外因(环境、吸烟、辐射等);涵盖所有7个致病原因(物理因素、化学因素、生物学因素、遗传因素、内分泌因素、免疫功能和精神因素);覆盖泌尿系统所有6个解剖部位(6/6,100%),10个统计病种(10/15,66.67%)。其中,吸烟、咖啡、茶和职业因素等为可能的致病原因。对于尿路上皮癌,医源性因素、慢性感染和下尿路梗阻也是可能致病因素。有3种泌尿系肿瘤可以预防,大部分疾病具有遗传和基因异常可能。泌尿系统肿瘤的病因覆盖所有致病因素,病因学研究可以为临床诊治提供依据。防患于未然,预防是关键。

关键词: 泌尿系统肿瘤, 病因, 诱因, 预防

Abstract: We reviewed through literature search and data analysis, we discussed the specific etiology and causes of urological tumors.The etiology of urological tumors include internal causes (heredity and variation) and external causes (environment, smoking, radiation, etc.), covering all 7 causes (physical, chemical, biological, genetic, endocrine, immune and mental factors); covering all 6 dissections of the urinary system (6/6100%), 10 statistical diseases (10/15, 66.67%). Among them, smoking occupied 3 anatomical parts (3/6, 50%) and 3 diseases (3/15, 20%). Coffee occupied 2 anatomical parts (2/6, 33.33%) and 2 diseases (2/15, 13.33%). Tea can increase the risk of kidney cancer, but it will reduce the risk of prostate cancer. Occupational factors occupy 3 anatomical sites (3/6, 50%), and 4 diseases (4/15, 26.67%). It is necessary for us to improve the occupational environment protection and conduct regular examination of specific occupations for early diagnosis and early treatment. The causes of urothelial carcinoma include iatrogenic factors such as chemotherapeutic cyclophosphamide, analgesics and Chinese herbal medicine (aristolochic acid, etc.). chronic infection and lower urinary tract obstruction are also a high risk factor. Some diseases can be prevented. The etiology of urologic tumors covers all pathogenic factors, and etiological research can provide evidence for clinical diagnosis and treatment. Prevention is the key.

Key words: urinary neoplasms, etiology, inducement, prevention