基础医学与临床 ›› 2019, Vol. 39 ›› Issue (2): 256-259.
• 短篇综述 • 上一篇 下一篇
覃娜,王艳华
收稿日期:
修回日期:
出版日期:
发布日期:
通讯作者:
基金资助:
Received:
Revised:
Online:
Published:
摘要： 骨肉瘤的发生机制与多种抑癌基因失活甚至缺失有关，其中包括PTEN、WWOX、WIF-1、SPARCL1和p53等，而这些基因均对骨肉瘤的生长具有抑制作用。甲基化是重要的表观遗传学特征之一，以‘抑癌基因甲基化’为骨架节点的相关研究为骨肉瘤的临床诊断、治疗及其发病机制的阐释提供了重要支撑，也为新型抗骨肉瘤药物的研发提供了巧妙思路。
关键词: 抑癌基因, 甲基化, 骨肉瘤, 治疗
Abstract: The pathogenesis mechanism of osteosarcoma closely related to the expression inactivation or even loss of multiple tumor suppressor genes, including PTEN, WWOX, WIF-1, SPARCL1, p53 and so on, which inhibited the growth of osteosarcoma. Methylation was one of the important epigenetic features, and the relevant studies about the methylation of these tumor suppressor genes provided valuable or fundamental support to clinical diagnosis, treatment and pathogenesis of osteosarcoma, which also offered an ingenious idea to develop new anti-osteosarcoma drugs.
Key words: tumor suppressor gene, methylation, osteosarcoma, treatment
覃娜 王艳华. 抑癌基因甲基化与骨肉瘤的关系[J]. 基础医学与临床, 2019, 39(2): 256-259.
0 / / 推荐
导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks
链接本文: http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/
http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2019/V39/I2/256
