基础医学与临床 ›› 2017, Vol. 37 ›› Issue (2): 261-264.
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李英杰,杨宝学
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摘要： 凝血酶激活的纤溶抑制物(TAFI)是一种能被凝血酶激活的血浆酶原。对凝血和纤溶起调节作用，具有很强的抗纤溶及抗炎活性。其抑制剂有望解决溶栓血管再通时避免出血的风险，同时，研究发现TAFI在脑血栓、动脉粥样硬化等心脑血管疾病的发生发展中起着至关重要的作用。
关键词: 凝血酶激活的纤溶抑制物, 脑血栓, 心血管病
Abstract: Thrombin activatable fibrinolysis inhibitor (TAFI) is a kind of plasma enzymes that can be activated by thrombin. TAFI regulates blood coagulation and fibrinolysis and has a strong fibrinolytic and anti-inflammatory activity. Its inhibitor is expected to avoid the risk of bleeding when thrombolytic recanalization. Also, studies found that TAFI played an important role in the development of cerebral thrombosis; atherosclerosis and so on.
Key words: thrombin activation of fibrinolysis inhibitor (TAFI), cerebral thrombosis, cardiovascular disease
中图分类号:
R966
李英杰 杨宝学. 凝血酶激活的纤溶抑制物在心脑血管疾病中的作用研究进展[J]. 基础医学与临床, 2017, 37(2): 261-264.
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