基础医学与临床 ›› 2017, Vol. 37 ›› Issue (12): 1765-1769.
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宋国栋,牛远杰
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摘要： Sox5定位于12p12.1，共包含29个外显子，可转录出5个异构体，其中L-SOX5A相对研究较多，其功能众多，如调节着胚胎发育、决定着细胞分化，还参与多种肿瘤的发生，如淋巴瘤、乳腺癌、胶质瘤和前列腺癌等。
关键词: Sox家族, Sox5, 细胞分化, 肿瘤转移
Abstract: Sox5 gene is located on 12p12.1, containing 29 exons, it can transcript 5 variants, thus produce 5 isoforms. L-SOX5A is an isoform relative extensive studied, its functions include regulate embryonic development, and determine cell differentiation. Sox5 was implicated in prostate cancer, breast cancer and lymphoma.
Key words: Sox family, Sox5, cell differentiation, tumor metastasis
宋国栋 牛远杰. Sox5与肿瘤的相关性研究进展[J]. 基础医学与临床, 2017, 37(12): 1765-1769.
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链接本文: http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/
http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2017/V37/I12/1765
