基础医学与临床 ›› 2017, Vol. 37 ›› Issue (12): 1733-1737.

• 研究论文 • 上一篇    下一篇

2种疾病患者尿液有机酸代谢谱主成分的确定及分析

马振菁1,黄建明2,吴珍琴3,郑秀芬3,林绥1,邓思珊1,刘洪旭1   

  1. 1. 福建省医学科学研究院
    2. 福建省测试技术研究所
    3. 福建省立医院
  • 收稿日期:2017-07-21 修回日期:2017-10-19 出版日期:2017-12-05 发布日期:2017-11-29
  • 通讯作者: 马振菁 E-mail:mzjing963@163.com
  • 基金资助:
    省属公益类科研院所基本科研专项

Principal component determination and analysis of urine organic acid metabolism spectrum of two diseases

  • Received:2017-07-21 Revised:2017-10-19 Online:2017-12-05 Published:2017-11-29
  • Contact: Zhen-jing MA E-mail:mzjing963@163.com

摘要: 目的 采用主成分分析法分析重症肌无力、线粒体肌病和健康者尿中22种有机酸代谢产物的特征,为临床筛查提供资料和依据。方法 通过获得主成分及相应的主成分方程,解释主成分的理化意义。结果 前5个主成分累积贡献率达到86.89%,被确定为主要成分;建立主成分函数表达式,分析主成分与原始变量之间的关系;发现苯基饱和酸类可能是2种疾病的潜在生物标记物成分;马尿酸为2种疾病预警成分。结论 尿有机酸代谢谱主成分分析,有助于疾病的生物标记物的发现和为辅助临床诊断提供科学依据。

关键词: 主成分分析1, 线粒体肌病2, 重症肌无力3, 尿有机酸代谢谱4

Abstract: Objective Analysis of 22 kinds of organic acid metabolites in myasthenia gravis, mitochondrial myopathy and healthy urine was performed so to provide data and basis for clinical screening. Methods The principal component and the corresponding principal component equation were obtained, and the physical and chemical significance of the principal component was explained. Results The cumulative contribution rate of the first five principal components reached 86.89%, was identified as the main component, then established the principal component function expression, and analyzed the relationship between the principal component and the original variable. It was found that the phenyl saturated acid might be a potential biomarker of the two diseases, and the hippuric acid was an early warning component of the two diseases.Conclusion Urine organic acid metabolic profile principal component analysis is helpful to find biomarker of disease and could assisted clinical diagnosis on the scientific basis.

Key words: Principal component analysis 1, Mitochondrial myopathy 2, Myasthenia gravis 3, Urine organic acid metabolic profile 4