小剂量阿司匹林的临床应用及其对心肌肥厚的心室重构的研究进展

基础医学与临床 ›› 2016, Vol. 36 ›› Issue (9): 1310-1312.

小剂量阿司匹林的临床应用及其对心肌肥厚的心室重构的研究进展

张琪¹,辛雪²,薛锋²,薛明明¹

1. 内蒙古医科大学
2. 内蒙古医科大学基础医学院

收稿日期:2015-12-03 修回日期:2016-05-03 出版日期:2016-09-05 发布日期:2016-08-30
通讯作者: 薛明明 E-mail:happybird-nmg@163.com

Progress on the clinicalappl application of low-dose aspirin and ventricular remodeling of myocardial hypertrophty

Received:2015-12-03 Revised:2016-05-03 Online:2016-09-05 Published:2016-08-30

摘要/Abstract

摘要： 阿司匹林的作用广泛,可以治疗中风等许多疾病。不同剂量的阿司匹林疗效不完全相同。小剂量阿司匹林(低于150mg)能不可逆的抑制环氧化酶(COX-1)活性,防止血栓形成,从而发挥延缓心肌肥厚的心室重构的作用。

关键词: 关键词:小剂量阿司匹林,心肌肥厚,心室重构

Abstract: The effect of aspirin is extensive, which can treat many diseases such as stroke.But curative effect of different doses of aspirin is not completely the same。In recent decades of research，we found that low-dose aspirin can irreversiblly inhibit the activity of epoxidase (COX-1), blocking the formation of thromboxane A2, inhibiting platelet aggregation, preventing thrombosis, thus it plays a role of delaying the progress of the ventricular remodeling of myocardial hypertrophy.

Key words: Key words:low-dose aspirin,cardiac hypertrophy,ventricular remodeling

张琪辛雪薛锋薛明明. 小剂量阿司匹林的临床应用及其对心肌肥厚的心室重构的研究进展[J]. 基础医学与临床, 2016, 36(9): 1310-1312.