基础医学与临床 ›› 2016, Vol. 36 ›› Issue (9): 1290-1294.

• 短篇综述 • 上一篇    下一篇

坏死性凋亡在神经系统疾病中作用的研究进展

孟俊杰,母得志,屈艺   

  1. 四川大学华西第二医院儿科
  • 收稿日期:2015-09-17 修回日期:2015-12-04 出版日期:2016-09-05 发布日期:2016-08-30
  • 通讯作者: 屈艺 E-mail:quyi712002@163.com
  • 基金资助:
    国家自然科学基金;四川科技厅公益民生项目;国家临床重点专科(儿科新生儿专业)建议项目

Roles of necroptosis in neurological diseases

  • Received:2015-09-17 Revised:2015-12-04 Online:2016-09-05 Published:2016-08-30
  • Supported by:
    National Natural Science Foundation of China

摘要: 坏死性凋亡在多种器官系统疾病的发生发展中起着关键作用。神经元死亡常见于各类神经系统疾病。近来发现,坏死性凋亡是神经元死亡的重要方式,抑制其坏死性凋亡可在一定程度上实现神经保护作用,也是今后神经系统疾病防治研究的重点。

关键词: 细胞死亡, 坏死性凋亡 , 神经系统

Abstract: Necroptosis plays crucial roles in the genesis and development of many diseases involved in different organisms and systems. Neuronal damage is common in all kinds of neurological diseases. According to recent reports, necroptosis is an important pattern of neuronal death. Inhibition of neuronal necroptosis shows protective roles in neurological diseases. Therefore, studies on neuronal necroptosis will be the focus of prevention and treatment of neurological diseases in the future.

Key words: cell death, necroptosis, nervous system

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