基础医学与临床 ›› 2016, Vol. 36 ›› Issue (10): 1429-1432.
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张春艳1,张富春2,马纪2,王莹3,徐存拴4
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摘要: 肝癌是世界上最常见的恶性肿瘤之一,其发病率和死亡率极高。microRNA(miRNA)是一类单链的非编码RNA,通常在转录后水平调控基因的表达。最近多项研究表明miRNA在肝癌中发挥着重要作用,已经成为肝癌诊断、治疗中的一个靶标。
关键词: 肝癌, miRNA, 诊断, 治疗
Abstract: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and the third cause of cancer-related death. MicroRNA (miRNA), a class of noncoding single-stranded RNAs, posttranscriptional regulate gene expression by base pairing with the 3’untranslated regions (3UTRs) of target messenger RNAs (mRNAs).Recent studies show that miRNA play an important role in HCC, it has become a target diagnostic biomarkers and therapy of HCC.
Key words: hepatocellular carcinoma, miRNA, diagnosis, therapy
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R735.7
张春艳 张富春 马纪 王莹 徐存拴. microRNA与肝癌[J]. 基础医学与临床, 2016, 36(10): 1429-1432.
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