基础医学与临床 ›› 2015, Vol. 35 ›› Issue (12): 1686-1690.
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贺茜1,邹秀兰2
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摘要： IKKε作为新发现的IKK相关激酶，通过介导非经典的NF-κB和IRF信号通路，在调控炎性反应、天然免疫、癌症形成等方面都具有重要的作用。同时，IKKε在代谢性疾病中的作用也逐渐被认识。IKKε与肥胖、2型糖尿病、非酒精性脂肪性肝病等密切相关，其作用机制主要包括促进组织炎性反应、加重胰岛素抵抗、影响能量代谢及脂肪因子分泌等方面。
关键词: IKKε, 2型糖尿病, 非酒精性脂肪肝
Abstract: IKKε known as a new IκB kinase(IKK)-related kinases play a vital role in regulating inflammation, innate immune response and oncogenesis through the activation of non-canonical NF-κB and IRF signaling cascades. Meanwhile, the role involved in the pathophysiology of metabolic diseases have gradually been found. IKKε have been closely linked to obesity, type 2 diabetes(T2DM)and non-alcoholic fatty liver disease（NAFLD）through the mechanism including producing inflammation, aggravating insulin resistance and effecting energy expenditure as well as andipokines secretion.
Key words: IKKε , type 2 diabetes, non-alcoholic fatty liver disease
中图分类号:
R589
贺茜 邹秀兰. IKKε影响代谢性疾病的相关机制研究进展[J]. 基础医学与临床, 2015, 35(12): 1686-1690.
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