基础医学与临床 ›› 2015, Vol. 35 ›› Issue (12): 1682-1685.

• 短篇综述 • 上一篇    下一篇

脂蛋白(a)与心脑血管疾病

官秀英1,2,赵建华1,周帅1,3   

  1. 1. 昆明理工大学附属医院
    2. 昆明理工大学医学院
    3. 云南省第一人民医院
  • 收稿日期:2015-04-29 修回日期:2015-06-24 出版日期:2015-12-05 发布日期:2015-12-04
  • 通讯作者: 赵建华 E-mail:zjh391km@163.com
  • 基金资助:
    昆明理工大学自然科学研究基金资助项目

Lipoprotein (a) and cardio-cerebrovascular disease

1,2, 4,4   

  • Received:2015-04-29 Revised:2015-06-24 Online:2015-12-05 Published:2015-12-04

摘要: 血浆脂蛋白(a)是心脑血管疾病发生的一个重要风险因子。脂蛋白(a)存在广泛的异质性,且研究显示其致病风险性与载脂蛋白(a)基因多态性和表型多态性相关联。然而,目前尚缺乏有效的降低脂蛋白(a)水平的药物和方法,但不可否认的是降脂治疗有利于降低心脑血管疾病的发生风险。

关键词: 脂蛋白(a), 多态性, 心脑血管疾病, 降脂治疗

Abstract: Plasma lipoprotein (a) is an important risk factor for cardio-cerebrovascular disease. Levels of lipoprotein (a) in plasma show widely heterogeneity, and the pathogenic risk of lipoprotein (a) is associated with apolipoprotein (a) gene polymorphism and phenotypic polymorphism. However, there are lack of effective therapy drugs and methods to lowing the lipoprotein (a) levels, but it is undeniable that lipid-lowering therapy is of great benefit to reduce the risk of the development of cardio-cerebrovascular disease.

Key words: lipoprotein (a), polymorphism, cardio-cerebrovascular disease, lipid-lowering therapy

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