基础医学与临床 ›› 2015, Vol. 35 ›› Issue (12): 1672-1676.
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谌芳1,吴意1,林雪迟2
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摘要: P53可通过阻滞细胞周期进程、诱导细胞凋亡,促进肿瘤细胞对化学药物的敏感性;在药物损伤或外在刺激的情况下,活化的P53还可能介导肿瘤细胞凋亡抑制,促进细胞药物的耐受;P53突变或功能丧失与促进肿瘤细胞耐药密切相关;P53介导肿瘤细胞耐药调控也有可能被忽略。不同肿瘤细胞中 P53对肿瘤细胞的作用不同,P53功能具有多效性。
关键词: P53, 肿瘤细胞, 耐药性, 调控
Abstract: P53 is involved in drug-resistance of carcinoma cells from multiple profiles, of which P53 improves drug-sensitivity in carcinoma cells through arresting cell cycle progression and inducing cellular apoptosis. Some special situations such as drug damages, external stresses and so on result in P53 activation, which might mediates drug-tolerance of carcinoma cells and inhibition of cellular apoptosis. Mutant P53 or disorder of P53, is also closely associated with promoting drug-tolerance of carcinoma cells. Besides above mentioned, the function of P53 mediated the resistance of tumor cells to drugs is probably flipped. P53 mediated the regulation of drug resistance in different carcinoma cells substantially presents a variety of possibilities.
Key words: P53, carcinoma cell, drug-resistance, regulation
谌芳 吴意 林雪迟. P53功能的多效性[J]. 基础医学与临床, 2015, 35(12): 1672-1676.
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