基础医学与临床 ›› 2015, Vol. 35 ›› Issue (1): 117-121.
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魏祺1,程晓曙2
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摘要： 炎性小体是一种多蛋白复合体，它能够识别多种病原微生物及应激相关内源性信号分子，在固有免疫中发挥重要作用。炎性小体可通过活化半胱氨酸天冬氨酸酶-1（caspase-1）诱导促炎因子IL-1β和IL-18的成熟、释放，引起炎性反应，参与多种疾病如家族性周期性自身炎性反应、缺血再灌注损伤和动脉粥样硬化等的发生发展过程。
关键词: 炎性小体, NLRP3, IL-1β
Abstract: Inflammasomes are multiprotein complexes that can recognize pathogenic microorganisms and stress-associated endogenous molecules and play an important role in innate immune system.Inflammasomes cause inflammatory response by inducing maturation of inflammatory cytokines interleukin(IL)-1β and IL-18 through activation of caspase-1,and involve in the pathogenesis of various diseases such as cryopyrin-associated periodic syndrome、ischemia-reperfusion injury and atherosclerosis.
Key words: inflammasome, NLRP3, IL-1β
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R5
魏祺 程晓曙. NLRP3炎性小体研究进展[J]. 基础医学与临床, 2015, 35(1): 117-121.
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